Exploring the prescription laws of bone flaccidity in ancient Chinese medical texts based on association rules and latent structure model  

作　　者：Yulu Yuan Ce Chu Xuguang Tao Zhen Yang Xiangyun Chen Wei Ding Zhanzhan He Yongqi Xu Yuxin Zhang Peizhang Zhao Wanping Chen Hongxia Zhao Wenlai Wang 

机构地区：[1]Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing,China [2]School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing,China [3]West China Clinical Medical College,Sichuan University,Chengdu,China

出　　处：《Guideline and Standard in Chinese Medicine》2024年第4期243-250,共8页中医规范与标准(英文)

基　　金：supported by China Academy of Chinese Medical Science and Technology Innovation Project Heidihuang Pill Major Research Project(No.CI2021A00606);China Academy of Chinese Medical Sciences Self-selected projects(YZX202237,YZX202241,YZX202246,YZ2020042,YZ202225,YZ2020019);Beijing Traditional TCM Science and Technology Development Fund Project(No.JJ2018-99).

摘　　要：Objective:To analyze the identification and typing of bone flaccidity and the law of medication in ancient books based on the Encyclopaedia of TCM(Traditional Chinese Medicine)using the hidden structure model.Methods:The formulations for bone flaccidity were searched in the Chinese Medical Code(software),based on which an Excel sheet was created to conduct frequency analysis and construct a matrix of high-frequency medications.The high-frequency medications for bone flaccidity were then analyzed using the Latent 5.0 software and a latent structure model.With SPSS Modeler and Latent 5.0 as the main analysis methods,Chinese medications with a frequency>1.00%were investigated using the latent structure model and association rules,and the medication rules in treating bone flaccidity with TCM were dissected based on the data of frequency.Results:A total of 223 TCM prescriptions were included,with 270 extracted TCM and a total medication frequency of 2340 times.Among them are Achyranthis Bidentatae Radix,Poria,Angelicae Sinensis Radix,Eucommiae Cortex,Rehmanniae Radix Praeparata,and Ginseng Radix Et Rhizoma.They were the high-frequency medicines for treating bone flaccidity,and the efficacy of tonifying medicinal,heat-clearing medicinal,and blood activating and stasis-resolving medicinal were high-frequency medicinal categories.Through the analysis of the evidence by formula,it was concluded that spleen-kidney yang deficiency,kidney deficiency and blood stasis,kidney yang deficiency,qi deficiency/qi stagnation and blood stasis,and liver and kidney yin deficiency were the 6 main types of bone flaccidity,which was generally in line with the etiology of bone flaccidity,which was caused by kidney yang deficiency and accompanied by malfunction of the liver and kidneys.In ancient books,the regulation of the kidney is put into an important position.In this study,19 correlative principles for the treatment of bone flaccidity were derived,whose main combinations are Paeoniae Radix Alba-Angelicae Sinensis Radix,Eucommiae Cortex+

关 键 词：association rules boneflaccidity latent structure model medication rules 

分 类 号：R69[医药卫生—泌尿科学]