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作 者:张夏丽 王卓 米丽[2] ZHANG Xia-li;WANG Zhuo;MI Li(The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Armed Police Force Shanghai General Hospital,Shanghai 201103,China)
机构地区:[1]海军军医大学第一附属医院,上海200433 [2]武警上海总队医院,上海201103
出 处:《解放军药学学报》2025年第1期31-37,共7页Pharmaceutical Journal of Chinese People's Liberation Army
基 金:上海市长宁区医疗卫生科研专项课题,No.CNKW2022Y64。
摘 要:目的基于数据挖掘分析中药复方治疗单纯性肥胖的用药频次及配伍规律,为临床用药及新药研发提供参考。方法检索中医药文献治疗单纯性肥胖的中药复方,采用Microsoft Excel 2019软件统计中药出现频次、性味归经和功效分类,根据中药类别绘制桑基流量图;采用Cytoscape 3.9.0软件对数据进行可视化处理,构建核心药物复杂共现网络,分析核心药物拓扑属性值及其关联性,筛选核心方。结果符合纳入标准的中药复方共381首,涉及中药253味,高频中药有茯苓、白术、泽泻等,以补虚药、利水渗湿药为主,多归脾、胃两经,常用对药有“白术-茯苓”“陈皮-茯苓”等7项,常用角药组合有“茯苓-白术-甘草”“茯苓-白术-泽泻”等37项,聚类分析得到高频中药聚类方“半夏-陈皮”等4组,深度分析挖掘出由茯苓、白术、泽泻、甘草、荷叶、山楂、陈皮、黄芪8味中药组成的治疗单纯性肥胖的核心中药处方。结论中药复方治疗单纯性肥胖常以健脾利湿、理气化痰、清胃泄火、泄浊逐瘀为原则选方用药,所得结果可为中药复方治疗单纯性肥胖的临床决策提供参考。Objective To analyze the DDDs and compatibility of compound formulae of TCM against simple obesity based on data mining.Methods Literature was searched for compound formulae of TCM against simple obesity.The frequency at which TCM was used,nature and taste meridian tropism and efficacy were analyzed with Excel 2019 software.A Sankey diagram was drawn according to the category of drugs.Association rule analysis and cluster analysis of core drugs were conducted by SPSS Modeler 18.0 and SPSS Statistic 26.0 software while the data was visualised by Cytoscape 3.9.0 software before a complex co-occurrence network of core drugs was constructed.The topological properties of core drugs and their correlations were analyzed to screen out the core formulae.Results A total of 381 compound formulae of TCM met the inclusion criteria,involving 253 types of TCMs.High-frequency Chinese medicines included Poria,Atractylodes macrocephala and Zedoary,which were mostly used to replenish deficiency,promote diuresis and remove dampness.The commonly used pairs of drugs included′Rhizoma Atractylodis-Poria cocos′and′Pericarpium Citri Reticulatae-Poria cocos′.There were 37 commonly used combinations,such as′Poria cocos-Rhizoma Atractylodis-Licorice′and′Poria cocos-Rhizoma Atractylodis-Rhizoma alismatis′.Cluster analyses yielded four groups of high-frequency compound formulae,including′Pinellia ternata-Pericarpium Citri Reticulatae′.In-depth mining suggested eight core compound formulae of TCM for the treatment of simple obesity,namely Poria cocos,Rhizoma Atractylodis,Rhizoma alismatis,Licorice,Lotus leaf,Fructus Crataegi,Pericarpium Citri Reticulatae,and Astragalus membranaceus.Conclusion In the treatment of simple obesity,compound formulae of TCM are normally based on the principles of strengthening the spleen and removing dampness,regulating qi and resolving phlegm,clearing the stomach and relieving heat,and eliminating turbidity and removing blood stasis.These results may contribute to the selection of treatments for
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