基于态靶辨证辨治Ⅱ型心肾综合征  

Treatment of type Ⅱ cardiorenal syndrome based on the theory of syndrome differentiation of state-target

作　　者：徐凡 崔玮璐 李海霞[1] XU Fan;CUI Weilu;LI Haixia(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《吉林中医药》2025年第3期274-277,共4页Jilin Journal of Chinese Medicine

基　　金：国家社会科学基金项目(21VJXG037);中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP-2023045);首都卫生发展科研专项重点攻关项目(2024-1-4151);国家中医药管理局第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)。

摘　　要：Ⅱ型心肾综合征是由慢性心力衰竭导致的肾功能障碍,复杂的病理生理机制和异质性增加了其诊疗难度。基于仝小林提出的“态靶辨证理论”,结合Ⅱ型心肾综合征病理生理特点,将其分为“虚态、瘀态、水态、浊态”四态,并结合现代中医学对心肾综合征的认识及药理学研究成果,选出“病靶”“证靶”“标靶”靶药。构建心肾综合征的态靶辨治理论体系,以期提供更精准有效的治疗方案。Type Ⅱ cardiorenal syndrome is a renal dysfunction caused by chronic heart failure,and its complex pathophysiological pathogenesis and heterogeneity increase the difficulty of diagnosis and treatment.In this paper,based on the"state-target syndrome differentiation theory"proposed by Academician Tong Xiaolin,combined with its pathophysiological characteristics,type Ⅱ cardiorenal syndrome is classified into four states,namely,"deficiency state,blood stasis state,water state and turbidity state".In addition,combined with the understanding of CRS in modern Chinese medicine and the results of its pharmacological research,the target drugs are selected for the"disease target","syndrome target",and"biochemical indicator target",respectively.This study is aimed at constructing a theoretical system of CRS state-target syndrome differentiation to provide more accurate and effective treatment solutions for its treatment.

关 键 词：态靶辨证 心力衰竭 心肾综合征 慢性肾脏病 

分 类 号：R541[医药卫生—心血管疾病]