重症肺炎合并心力衰竭患儿应用多巴酚丁胺联合西地兰治疗的效果分析  

Analysis of the Effect of Dobutamine Combined with Deslanoside Treatment in Children with Severe Pneumonia Complicated with Heart Failure

作　　者：何颜翔 王豪 HE Yanxiang;WANG Hao(Kaifeng Children's Hospital,Kaifeng Henan 475000,China.)

机构地区：[1]开封市儿童医院,河南开封475000

出　　处：《药品评价》2024年第11期1374-1377,共4页Drug Evaluation

摘　　要：目的 探究多巴酚丁胺联合西地兰对重症肺炎(SP)合并心力衰竭(HF)患儿的影响。方法 选取2021年1月至2024年1月开封市儿童医院就诊的SP合并HF患儿80例,采用随机数字表法分为对照组、观察组。其中给予西地兰的40例为对照组,给予多巴酚丁胺联合西地兰的40例为观察组。比较两组临床疗效,不良反应发生率,治疗后临床症状改善时间(呼吸、烦躁、心率、肺啰音),治疗前后心肌酶谱[B型脑钠肽(BNP)、乳酸脱氢酶(LDH)、心肌肌钙蛋白(cTnI)、肌酸激酶同工酶MB(CK-MB)]及血清炎症因子[肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)、白介素(IL)-6、IL-8]水平。结果 两组临床总有效率比较,差异有统计学意义(92.50%vs 75.00%,P<0.05)。治疗后,观察组呼吸、烦躁、心率、肺啰音改善时间低于对照组(P<0.05);观察组BNP、LDH、cTnI、CK-MB水平低于对照组(P<0.05);观察组TNF-α、CRP、IL-6、IL-8水平低于对照组(P<0.05)。观察组不良反应发生率15.00%与对照组10.00%相比,差异无统计学意义(P>0.05)。结论 多巴酚丁胺联合西地兰治疗SP合并HF疗效显著,可缓解临床症状,调节心肌酶谱、降低体内炎症反应,安全可靠。Objective To explore the effects of dobutamine combined with deslanoside on children with severe pneumonia(SP)complicated with heart failure(HF).Methods Eighty children with SP combined with HF who were treated in Kaifeng Children's Hospital from January 2021 to January 2024 were selected and divided into a control group and an observation group using a random number table method.Among them,40 cases given deslanoside were in the control group,and 40 cases given dobutamine plus deslanoside were in the observation group.The clinical efficacy,incidence of adverse reactions,and time for clinical symptom improvement(respiration,irritability,heart rate,lung rale)were compared between the two groups,as well as the changes in myocardial enzyme spectrum[B-type natriuretic peptide(BNP),lactate dehydrogenase(LDH),cardiac troponin I(cTnI),creatine kinase MB(CK-MB)]and serum inflammatory factors[tumor necrosis factor(TNF)-α,C-reactive protein(CRP),interleukin(IL)-6,IL-8]levels before and after treatment.Results The total effective rate of the two groups was significantly different(92.50%vs 75.00%,P<0.05).After treatment,the improvement time of breathing,irritability,heart rate and pulmonary rales in the observation group were lower than those in the control group(P<0.05);the levels of BNP,LDH,cTnI and CK-MB in the observation group were lower than those in the control group(P<0.05);the levels of TNF-α,CRP,IL-6 and IL-8 in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(15.00%)and the control group(10.00%)(P>0.05).Conclusion Dobutamine combined with deslanoside is effective in the treatment of SP complicated with HF,which can relieve clinical symptoms,regulate myocardial enzyme spectrum,reduce inflammatory reaction in vivo,and is safe and reliable.

关 键 词：多巴酚丁胺 西地兰 重症肺炎 心力衰竭 心肌酶谱 

分 类 号：R54[医药卫生—心血管疾病]