喜炎平联合阿莫西林-克拉维酸钾治疗小儿支原体肺炎对患儿康复进程与微炎症状态的影响  

Effect of Xiyanping Combined with Amoxicillin and Clavulanate Potassium in the Treatment of Mycoplasma Pneumonia in Children on the Recovery Rrocess and Microinflammatory State

作　　者：许文霖 饶志辉 吴海霞 刘羊坡 XU Wenlin;RAO Zhihui;WU Haixia;LIU Yangpo(Jiangxi Maternal and Child Health Care Hospital,Nanchang Jiangxi 330103,China)

机构地区：[1]江西省妇幼保健院,江西南昌330103

出　　处：《药品评价》2024年第11期1402-1405,共4页Drug Evaluation

摘　　要：目的 为分析喜炎平联合阿莫西林-克拉维酸钾治疗小儿支原体肺炎的疗效及对患儿康复进程与微炎症状态的影响。方法 本研究前瞻性选取2022年1月至2024年1月在江西省妇幼保健院就诊的小儿支原体肺炎患儿120例,随机分为对照组和试验组,各60例。两组均进行基础用药治疗,对照组加用阿莫西林克-拉维酸钾治疗,试验组在对照组的基础上联合喜炎平治疗。观察两组的康复进程、疗效、不良反应,比较两组的中医症状评分、肺功能指标及微炎症状态的变化。结果 连续治疗7天后,试验组的康复进程比对照组快,其发热消失时间、咳嗽咳痰消失时间、肺部湿啰音消失时间、X线检查肺部阴影消失时间均比对照组短(均P<0.05);中医症状评分、白细胞介素-6(IL-6)、白细胞介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)均下降,而最大呼气中期流速(MMF)、最大呼气流量(PEF)、用力肺活量(FVC)增加,与治疗前相比差异有统计学意义(均P<0.05),试验组中医症状评分、IL-6、IL-33、TNF-α、hs-CRP低于对照组,而MMF、PEF、FVC高于对照组(均P<0.05)。对照组的总有效率低于试验组(P<0.05),而两组不良反应差异无统计学意义(P>0.05)。结论 喜炎平联合阿莫西林-克拉维酸钾治疗小儿支原体肺炎或通过改善患儿的微炎症状态与肺功能,缩短其康复进程,疗效显著且安全性良好。Objective To analyze the curative effect of xiyanping combined with amoxicillin and clavulanate potassium in the treatment of mycoplasma pneumonia in children and the influence on the recovery process and microinflammatory state of children.Methods This study prospectively selected 120 children with mycoplasma pneumonia who were treated in Jiangxi Maternal and Child Health Hospital from January 2022 to January 2024,and were randomly assigned into the control group and the experimental group,each consisting of 60 cases.Both groups were treated with basic medication treatment,the control group was treated with amoxicillin and clavulanate potassium,and the experimental group was combined with xiyanping treatment on the basis of the control group.The rehabilitation process,curative effect and adverse reactions of the two groups were observed,and the changes of TCM symptom score,pulmonary function index and microinflammation status were compared between the two groups.Results After 7 days of continuous treatment,the recovery process of the experimental group was faster than that of the control group,and the disappearance time of fever,cough and sputum,lung moist rales and lung shadow by X-ray examination were shorter than that of the control group(all P<0.05);TCM symptom score,interleukin-6(IL-6),interleukin-33(IL-33),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)all decreased,while maximum mid-expiratory flow rate(MMF),maximum expiratory flow rate(PEF)and forced vital capacity(FVC)increased,compared with before treatment,there were significant differences(all P<0.05);the TCM symptom score,IL-6,IL-33,TNF-αand hs-CRP of the experimental group were lower than those of the control group,while MMF,PEF and FVC were higher than those of the control group(all P<0.05).The total effective rate of the control group was significantly lower than that of the experimental group(P<0.05),while there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Xiyanping c

关 键 词：小儿支原体肺炎 喜炎平 阿莫西林-克拉维酸钾 微炎症状态 康复进程 

分 类 号：R72[医药卫生—儿科]