EPCs/TLRs在新生血管性年龄相关性黄斑变性中的研究进展  

Advances in endothelial progenitor cells/toll like receptors in neovascular age-related macular degeneration

作　　者：王昌琴 李鉴峰 吕洋 Wang Changqin;Li Jianfeng;Lyu Yang(Ophthalmic Center,the 940 Hospital of Joint Service Support Forces of the Chinese People's Liberation Army,Lanzhou 730000,Gansu Province,China;The First Clinical Medical School,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院眼科中心,甘肃省兰州市730000 [2]甘肃省中医药大学第一临床医学院,甘肃省兰州市730000

出　　处：《国际眼科杂志》2025年第4期577-582,共6页International Eye Science

基　　金：国家自然科学基金资助项目(No.82000926);甘肃省卫生健康委员基金资助项目(No.GSWSKY2022-05);甘肃省自然科学基金项目(No.24JRRA003);联勤保障部队第九四〇医院院基金项目(No.2021yxky033,2023YXKY011,2023YXKY033);军队课题项目(No.24BJZ41);联勤保障部队第九四〇医院高层次人才培养工程项目(No.2024-G2-4)。

摘　　要：新生血管性年龄相关性黄斑变性(ARMD)是指各种原因诱导的脉络膜新生血管形成(CNV),导致黄斑出血、液体积聚和纤维化,在视野中央形成一个巨大的、黑色的暗点,导致90%以上的患者严重中心视力丧失。内皮祖细胞(EPCs)是一组异质性的细胞,在新生血管形成中发挥着重要作用,在病理性刺激下EPCs被动员到周围循环中,定向迁移到无血管区域,并促进受损区域的血管恢复和再内皮化。Toll样受体(TLRs)是一种模式识别受体和Ⅰ型跨膜蛋白,主要表达于单核细胞、树突状细胞等免疫细胞,识别病原微生物的表面,将信号传递给细胞,参与机体的先天免疫和获得性免疫。有研究表明绝大多数TLRs参与了新生血管的发展且EPCs能够表达TLRs。因此探究EPCs/TLRs对于ARMD的作用机制有助于我们对疾病的理解,可能为今后的靶向治疗提供新思路。Neovascular age-related macular degeneration(ARMD)is a condition where various causes induce the formation of choroidal neovascularization(CNV)in the macula,leading to macular hemorrhage,accumulation of fluid,and development of fibrosis,resulting in a large,dark spot in the center of the visual field,causing severe central vision loss in over 90% of patients.Endothelial progenitor cells(EPCs)are a heterogeneous group of cells that play a crucial role in neovascularization.Under pathological stimulation,EPCs are mobilized into the systemic circulation,migrate toward the avascular zone,and promote the restoration of blood vessels and endothelialization in the damaged area.Toll-like receptors(TLRs)are pattern recognition receptors and type Ⅰ transmembrane proteins that are mainly expressed in monocytes,dendritic cells,and other immune cells,recognizing the surface of pathogens and transmitting signals to cells,participating in the innate immune response and adaptive immune response.Studies have shown that most TLRs are involved in the development of neovascularization,and EPCs can express TLRs.Therefore,exploring the role of EPCs/TLRs in the pathogenesis of ARMD can help us understand the disease and may provide new insights for targeted therapy in the future.

关 键 词：Toll样受体(TLRs) 内皮祖细胞(EPCs) 新生血管性年龄相关性黄斑变性 SDF-1/CXCR4 

分 类 号：R54[医药卫生—心血管疾病]