角膜荧光素钠染色对iTrace视觉功能分析仪检查的影响  

Influence of corneal fluorescein sodium staining on test results of iTrace visual function analyzer

作　　者：尹欣 刘庆言 绍校 薛敏 陆瑶 马书营 史春生 Yin Xin;Liu Qingyan;Shao Xiao;Xue Min;Lu Yao;Ma Shuying;Shi Chunsheng(Department of Ophthalmology,Anhui No.2 Provincial People's Hospital(Anhui Eye Hospital),Hefei 230011,Anhui Province,China)

机构地区：[1]安徽省第二人民医院(安徽省眼科医院)眼科,安徽省合肥市230011

出　　处：《国际眼科杂志》2025年第4期680-684,共5页International Eye Science

摘　　要：目的:研究角膜荧光素钠(NaF)染色对iTrace视觉功能分析仪(简称iTrace)检查结果的影响。方法:前瞻性队列研究。招募2024-04/11于安徽省眼科医院门诊就诊的屈光不正患者100例100眼,分成试验组和对照组各50例50眼(均选取右眼纳入研究),试验组行角膜荧光素钠染色试纸染色,对照组予以0.9%生理盐水1滴滴眼,分别于干预前,干预后5、10、20 min进行iTrace检查,记录并比较各时间检查的角膜总高阶像差、球差、彗差、三叶草差、最佳球面值(RO值)、非球面因子(Q值)、角膜上下屈光力差(IS值)。结果:两组患者的基线水平比较无差异(均P>0.05)。组内比较发现试验组NaF染色后5 min测量的总高阶像差、球差、彗差、三叶草差较染色前明显增加(均P<0.05);组间比较发现,试验组干预后5 min时iTrace测量的角膜总高阶像差、球差、彗差、三叶草差变化(与基线差值)明显大于对照组(均P<0.05),两组干预后10、20 min时测量的iTrace各参数变化量(与基线差值)比较无差异(均P>0.05)。两组RO值、Q值、IS值比较无差异(均P>0.05)。结论:角膜NaF染色后会使iTrace测量的波前像差数值(角膜总高阶像差、球差、彗差、三叶草差)短时间内增加,随着时间的延长这种影响逐渐消失;而对角膜地形图参数(RO值、Q值、IS值)的测量无影响。AIM:To investigate the impact of corneal fluorescein sodium(NaF)staining on the examination results of iTrace visual function analyzer(iTrace).METHODS:Prospective cohort study.Totally 100 patients(100 eyes)with ametropia who visited the outpatient department of Anhui Eye Hospital from April to November 2024 were recruited.They were divided into an experimental group and a control group,with 50 patients(50 eyes,and only the right eyes were selected for inclusion)in each group.In the experimental group,corneal staining was performed using fluorescein sodium staining test strips,while in the control group,1 drop of 0.9%normal saline was instilled into the eyes.The iTrace examination was conducted before the intervention and at 5,10,and 20 min after the intervention.The total corneal higher-order aberrations,spherical aberration,coma aberration,trefoil aberration,best sphere value(RO value),asphericity factor(Q value),and corneal vertical refractive power difference(IS value)at each time of examination were recorded and compared.RESULTS:There was no statistically significant difference in the baseline levels between the two groups(all P>0.05).Intra-group comparison revealed that the total higher-order aberrations,spherical aberration,coma aberration,and trefoil aberration measured 5 min after NaF staining in the experimental group were significantly increased compared with those before staining(all P<0.05).Inter-group comparison showed that the changes(differences from the baseline)in the total corneal higher-order aberrations,spherical aberration,coma aberration,and trefoil aberration measured by iTrace 5 min after the intervention in the experimental group were significantly greater than those in the control group(all P<0.05).There was no statistically significant difference in the changes(differences from the baseline)of various iTrace parameters measured at 10 and 20 min after the intervention between the two groups(all P>0.05).There was no statistical significance in the RO value,Q value,and IS value in the two

关 键 词：角膜荧光素钠染色 iTrace检查 波前像差 

分 类 号：R47[医药卫生—护理学]