应激条件下烟曲霉参与的毒力相关信号通路  

Signal Pathways Related to the Virulence of Aspergillus fumigatus under Stress Conditions

作　　者：高靓 马彦[1] GAO Liang;MA Yan(Department of Dermatology and Venereology,the Second Hospital of Shanxi Medical University,Taiyuan,030001,China)

机构地区：[1]山西医科大学第二医院皮肤性病科,太原市030001

出　　处：《医学分子生物学杂志》2025年第2期200-204,210,共6页Journal of Medical Molecular Biology

基　　金：山西省基础研究计划自然科学研究面上项目(No.202103021224416)。

摘　　要：烟曲霉是一种常见的机会性致病菌,其孢子大量存在于人类生活的环境中,是造成侵袭性曲霉病的主要病因,感染率和死亡率均高。烟曲霉具有抵抗和适应不良环境的能力,这与它们的毒力密切相关,是治疗烟曲霉感染的关键。在面对不同应激条件下,烟曲霉未折叠蛋白反应通路、高渗透压甘油通路、细胞壁完整性通路和钙-钙调磷酸酶通路的组成和各成分对烟曲霉生长、毒力和抗菌药物耐药性均产生影响,为治疗侵袭性曲霉病的新一代药物开发提供新思路。Aspergillus fumigatus(A.fumigatus)is a common opportunistic pathogen.Its spores are abundant in the human environment and are the main cause of invasive aspergillosis,with high infection rate and mortality rate.The ability of A.fumigatus to resist and adapt to adverse environments is closely related to their virulence and is the key to the treatment of A.fumigatus infection.This review introduces the signal transduction pathways,including the unfolded protein response pathway,high osmolarity glycerolpathway,cell wall integrity pathway and calcium-calcineurin pathway,in A.fumigatus under different stress conditions and their effects on the growth,virulence and resistance to antifungal drugs.It provides new ideas for the development of innovative drugs for the treatment of invasive aspergillosis.

关 键 词：烟曲霉 应激 毒力 信号转导 

分 类 号：R379.6[医药卫生—病原生物学]