HFNC与NPPV治疗对AECOPD合并II型呼衰患者血气指标和复发率的影响  

Effects of HFNC and NPPV on blood gas indicators and recurrence rate in patients with AECOPD complicated with type II respiratory failure

作　　者：韩军侠 王举 王玉宏 HAN Junxia;WANG Ju;WANG Yuhong(Department of Respiratory and Critical Care Medicine,Suixi County Hospital,Huaibei,Anhui,China,235100)

机构地区：[1]安徽省濉溪县医院呼吸与危重症医学科,安徽淮北235100

出　　处：《分子诊断与治疗杂志》2025年第2期239-242,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省卫生健康科研项目(AHWJ2022b103)。

摘　　要：目的分析经鼻高流量氧疗(HFNC)、无创正压通气(NPPV)治疗对慢性阻塞性肺疾病急性加重(AECOPD)合并II型呼衰患者血气指标和复发率的影响。方法选取安徽省濉溪县医院2022年5月至2024年5月收治的160例AECOPD合并II型呼衰患者为研究对象,依照随机化分组法分为NPPV组(n=80)和HFNC组(n=80)。NPPV组实施NPPV治疗,HFNC组实施HFNC治疗。比较两组治疗基本情况(呼衰改善时间、通气治疗时间、住院时间),比较两组治疗前、治疗后循环指标[心率(HR)、呼吸频率(RR)]、血气指标[氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))、氧合指数(OI)],统计两组治疗期间并发症发生率以及两组复发情况。结果HFNC组呼衰改善时间、通气治疗时间、住院时间均低于NPPV组,差异有统计学意义(P<0.05)。治疗后,两组HR、RR、PaCO_(2)均低于治疗前,且HFNC组低于NPPV组,差异有统计学意义(P<0.05);两组PaO_(2)、OI均高于治疗前,且HFNC组高于NPPV组,差异有统计学意义(P<0.05)。两组并发症发生率、复发率比较差异无统计学意义(P>0.05)。结论HFNC治疗可显著改善AECOPD合并II型呼衰患者氧合及循环功能,加快患者恢复进程,治疗安全性高、复发率低,对其预后更为有利。Objective To analyze the influence of high-flow nasal cannula oxygen therapy(HFNC)and non-invasive positive pressure ventilation(NPPV)on blood gas indicators and recurrence rate in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with type II respiratory failure.Methods 160 patients with AECOPD complicated with type II respiratory failure admitted to the Hospital of Suixi County,Anhui Province were selected as the research subjects from May 2022 to May 2024.Using the randomization grouping method,the patients were divided into the NPPV group(n=80)and the HFNC group(n=80).The NPPV group received treatment with NPPV,while the HFNC group received treatment with HFNC.Various factors,such as the improvement time of respiratory failure,ventilation treatment time,and hospital stay,were compared between the two groups.Circulation indicators like heart rate(HR)and respiratory rate(RR),as well as blood gas indicators such as partial pressure of oxygen(PaO_(2)),partial pressure of carbon dioxide(PaCO_(2)),and oxygenation index(OI)were also compared before and after treatment.The incidence rate of complications during treatment and the recurrence of patients in both groups were recorded and analyzed.Results The respiratory failure improvement time,ventilation treatment time and length of hospital stay in the HFNC group were shorter than those in the NPPV group(P<0.05).Following treatment,HR,RR,and PaCO_(2)in the two groups were lower compared to before treatment,with the indicators in HFNC group showing lower values than the NPPV group(P<0.05).Additionally,PaO_(2)and OI in both groups post-treatment compared to before treatment,with the HFNC group exhibiting higher values than the NPPV group(P<0.05).There were no significant differences in the incidence of complications or recurrence rates between the two groups(P>0.05).Conclusion HFNC treatment for AECOPD patients with type II respiratory failure can significantly improve oxygenation and circulation function,accelerating the recov

关 键 词：慢性阻塞性肺疾病急性加重 II型呼吸衰竭 经鼻高流量氧疗 无创正压通气 血气指标 

分 类 号：R56[医药卫生—呼吸系统]