肺炎支原体感染患儿PLR、G-CSF、CCL17水平与病情严重程度的关系  

Relationship between PLR,G-CSF,CCL17 levels and the severity of Mycoplasma pneu-moniae infection in children

作　　者：张怀坤 刘严 曹原 ZHANG Huaikun;LIU Yan;CAO Yuan(Huaibei Maternal and Child Health Hospital of Anhui Province,Huaibei,Anhui,China,235000)

机构地区：[1]安徽省淮北市妇幼保健院儿二科,安徽淮北235000

出　　处：《分子诊断与治疗杂志》2025年第2期255-258,共4页Journal of Molecular Diagnostics and Therapy

基　　金：2021年度安徽省卫生健康委科研项目(AHWJ2021b044)。

摘　　要：目的探讨分析肺炎支原体感染患儿血小板与淋巴细胞比值(PLR)、粒细胞集落刺激因子(G-CSF)、趋化因子配体17(CCL17)水平与病情严重程度的相关性。方法回顾选取2020年5月至2024年5月淮北市妇幼保健院儿科收治的112例肺炎支原体感染患儿的临床资料,经剔除22例病例,最终纳入90例患儿,根据患儿病情严重程度分为轻症组41例及重症组49例。比较两组患儿的一般资料及PLR、G-CSF、CCL17水平,采用Pearson相关性分析PLR、G-CSF、CCL17与肺炎支原体感染重症患儿临床特征的关系,并绘制受试者工作特征(ROC)曲线分析PLR、G-CSF、CCL17评估肺炎支原体感染病情严重程度的应用价值。结果重症组抗生素使用时间、CRP及PLR、G-CSF、CCL17均高于轻症组,差异有统计学意义(P<0.05);重症组PCIS评分低于轻症组,差异有统计学意义(P<0.05);PLR、G-CSF、CCL17与CRP水平均呈正相关(P<0.05),PLR、G-CSF、CCL17与PCIS评分均呈负相关(P<0.05);ROC曲线分析显示:PLR、G-CSF、CCL17联合评估肺炎支原体感染病情严重程度的曲线下面积(AUC)=0.941,敏感度为83.7%、特异度为97.6%,诊断价值高于单一检测(P<0.05)。结论肺炎支原体感染患儿PLR、G-CSF、CCL17水平与病情严重程度密切相关,三者联合评估肺炎支原体感染病情严重程度具有较高的诊断价值。Objective To investigate the correlation between platelet to lymphocyte ratio(PLR),granulocyte colony-stimulating factor(G-CSF),chemokine ligand 17(CCL17)and the severity of the disease in children infected with Mycoplasma pneumoniae.Methods The clinical data of 112 children with Mycoplasma pneumoniae infection admitted to the Department of Pediatrics at Huaibei Maternal and Child Health Hospital from May 2020 to May 2024 were retrospectively selected.After inclusion and exclusion,22 cases were excluded,and 90 cases were finally included.Based on the severity of the disease,the children were divided into 41 cases in the mild group and 49 cases in the severe group.General data and levels of PLR,G-CSF,and CCL17 were compared between the two groups.Pearson correlation was used to analyze the relationship between PLR,G-CSF,and CCL17 and the clinical characteristics of severe children with Mycoplasma pneumoniae infection.The application value of receiver operating characteristic(ROC)curve analysis of PLR,G-CSF,and CCL17 in evaluating the severity of Mycoplasma pneumoniae infection was also drawn.Results The duration of antibiotic use,CRP,PLR,G-CSF,and CCL17 in the severe group were higher than those in the mild group.The differences were statistically significant(P<0.05),and the PCIS score in the severe group was lower than that in the mild group.The differences were statistically significant(P<0.05).PLR,G-CSF,and CCL17 were positively correlated with CRP levels(P<0.05),and PLR,G-CSF,and CCL17 were negatively correlated with PCIS scores(P<0.05).The ROC curve analysis showed that the area under the curve(AUC)of PLR,G-CSF,and CCL17 combined to evaluate the severity of Mycoplasma pneumoniae infection was 0.941.The sensitivity was 83.7%,the specificity was 97.6%,and the diagnostic value was higher than that of a single test(P<0.05).Conclusion The levels of PLR,G-CSF,and CCL17 in children with Mycoplasma pneumoniae infection are closely related to the severity of the disease.The combined assessment of these three factors h

关 键 词：肺炎支原体感染 儿童 血小板与淋巴细胞比值 粒细胞集落刺激因子 趋化因子配体17 病情严重程度 

分 类 号：R725.6[医药卫生—儿科]