银翘散加减对急性扁桃体炎患儿血清SAA、TNF-α、CRP、IL-17的影响  

Effect of modified Yinqiaosan on serum SAA,TNF-α,CRP and IL-17 in children with tonsillitis

作　　者：陆玲 陈冀伟 俞琴芳 朱伟雄 沈君英 LU Ling;CHEN Jiwei;YU Qinfang;ZHU Weixiong;SHEN Junying(Department of Pediatrics,Shanghai Jinshan District Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai,China,201501)

机构地区：[1]上海市金山区中西医结合医院儿科,上海201501

出　　处：《分子诊断与治疗杂志》2025年第2期263-266,共4页Journal of Molecular Diagnostics and Therapy

基　　金：上海市金山区中西医结合医院科研课题(2020-1)。

摘　　要：目的探究银翘散加减对急性扁桃体炎患儿血清淀粉样蛋白A(SAA)、肿瘤坏死因子α(TNF-α)、C-反应蛋白(CRP)、白细胞介素17(IL-17)的影响。方法选取2020年7月至2024年7月上海市金山区中西医结合医院儿科治疗的102例急性扁桃体炎患儿,随机分成对照组(49例)和联合组(53例)。对照组给予常规西医治疗;联合组给予常规西医治疗联合银翘散加减治疗。对比两组临床治疗效果。结果治疗5 d后,联合组的咽痛消失、脓性分泌物消退、扁桃体消肿及退热时间均较对照组短,差异有统计学意义(P<0.05);治疗5 d后,联合组的咽痛、发热、扁桃体充血、肿大、化脓、便干等中医证候积分均较对照组低,差异有统计学意义(P<0.05);治疗5 d后,联合组患儿的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗5 d后,联合组的血SAA、TNF-α、CRP、IL-17、WBC、NEU水平均低于对照组,差异有统计学意义(P<0.05)。结论银翘散加减可改善急性扁桃体炎患儿的炎症因子水平,促进患儿临床症状、体征改善,有效缩短康复时间,疗效确切。Objective To ascertain the repercussions of modified Yinqiaosan on serum TNF-α,CRP and IL-17 in children with acute tonsillitis.Methods A prospective study was conducted on 102 children with acute tonsillitis discharged from the Department of Paediatrics at Jinshan District Combined Traditional Chinese and Western Medicines Hospital,Shanghai,between July 2020 and July 2024.The data were categorized into a reference group(49 cases)and a comparative group(53 cases)depending on the order of consultation time.The reference group received traditional Western medicine treatments,while the comparison group received traditional Western medicine treatments combined with modified Yinqiaosan.The aim was to evaluate the clinical outcomes of the two cohorts.Results After 5 days of therapy,the resolution time of sore throat,elimination time of purulent secretion,swollen tonsils time,and temperature drop time were all significantly shorter in the integrated group than in the reference group,with a notable statistical discrepancy(P<0.05).Following 5 days of therapy,the severity of symptoms in the combined group was significantly reduced relative to the reference group.This discrepancy was statistically noteworthy(P<0.05).After to 5 days of therapy,the overall treatment response rate in the integrated group was significantly higher than in the referenced group.This discrepancy was statistically noteworthy(P<0.05).Following 5 days of therapy,blood SAA,TNF-α,CRP,WBC,and NEU levels in the combined group exhibited a diminution in relation to those of the reference group,with statistical significance.The reference group exhibited statistically notable outcomes(P<0.05).Conclusion Modified Yinqiaosan has been shown to increase inflammatory factors in children with tonsillitis,which helps alleviate clinical symptoms and signs.Furthermore,its effectiveness has been proven to reduce recovery time with a high degree of accuracy.

关 键 词：银翘散加减 急性扁桃体炎 血清淀粉样蛋白A 肿瘤坏死因子α C-反应蛋白 白细胞介素17 

分 类 号：R276.1[医药卫生—中医五官科学]