血清NT-pro BNP、ET-1与早产儿动脉导管未闭病情程度的关系  

Relationship between serum NT-pro BNP,ET-1 and the severity of patent ductus arteriosus in premature infants

作　　者：姚芒 刘丽娜[2] 封丽娟 黄慧洁[1] YAO Mang;LIU Lina;FENG Lijuan;HUANG Huijie(Department of Neonatology,Affiliated Hospital of Chengde Medical College,Chengde,Hebei,China 067000;Department of Pediatric Internal Medicine,Affiliated Hospital of Chengde Medical College,Chengde,Hebei,China,067000;Department of Pediatrics,Chengde Hospital of Traditional Chinese Medicine,Chengde,Hebei 067000,China)

机构地区：[1]承德医学院附属医院新生儿科,河北承德067000 [2]承德医学院附属医院小儿内科,河北承德067000 [3]承德市中医院儿科,河北承德067000

出　　处：《分子诊断与治疗杂志》2025年第2期267-270,共4页Journal of Molecular Diagnostics and Therapy

基　　金：承德市科技计划项目(202001A055)。

摘　　要：目的分析血氨基酸B型钠尿肽前体(NT-pro-BNP)、内皮素-1(ET-1)与早产儿动脉导管未闭(PDA)病情程度的关系。方法分析2020年3月至2023年3月承德医学院附属医院PDA早产儿96例临床资料。选取无PDA早产儿42例为非PDA组。根据疾病程度将PDA患儿分为轻度组(n=30)、中度组(n=32)及重度组(n=34)。比较各组NT-proBNP、ET-1水平差异,采用Spearman分析NT-proBNP、ET-1水平与早产儿PDA病情程度的关系。结果PDA组NT-proBNP水平、ET-1水平高于非PDA组,差异有统计学意义(P<0.005);PDA组DA值、LA/AO高于非PDA组,差异有统计学意义(P<0.005);疾病不同程度血NT-proBNP水平及DA值、LA/AO差异有统计学意义(P<0.005);疾病不同程度血ET-1水平差异无统计学意义(P>0.05);血NT-proBNP水平与DA、LA/AO均呈正相关,与DA/LPA负相关(P<0.05)。结论NT-proBNP与早产儿PDA病情程度具有相关性,可为早产儿PDA诊疗提供依据,ET-1水平与其关系仍需进一步研究。Objective To analyze the relationship between serum N-terminal pro-brain brain natriuretic peptide(NT-pro-BNP),endothelin-1(ET-1)and the severity of patent ductus arteriosus(PDA)in premature infants.Methods The clinical data of 96 premature infants with PDA in the hospital were analyzed between March 2020 and March 2023.A total of 42 premature infants without PDA were enrolled as non-PDA group.According to disease severity,PDA infants were divided into mild group(n=30),moderate group(n=32)and severe group(n=34).The levels of NT-proBNP and ET-1 in different groups were compared.The relationship between NT-proBNP,ET-1 levels and PDA severity in premature infants was analyzed by Spearman analysis.Results The levels of NT-proBNP and ET-1 in PDA group were higher than those in non-PDA group(P<0.005),DA and LA/AO were greater than those in non-PDA group(P<0.005).There were significant differences in serum NT-proBNP,DA and LA/AO among premature infants with different disease severity(P<0.005),but there was no significant difference in level of serum ET-1(P>0.05).The level of serum NT-proBNP was positively correlated with DA and LA/AO,while negatively correlated with DA/LPA(P<0.05).Conclusion NT-proBNP is correlated with PDA severity in premature infants,which can provide evidence for PDA treatment.The relationship between ET-1 level and PDA severity still needs further study.

关 键 词：早产儿 动脉导管未闭 血氨基酸B型钠尿肽前体 内皮素-1 

分 类 号：R722.6[医药卫生—儿科]