PDW、D-D、miR-223表达与重症MPP患儿病情及预后的相关性  

Correlation between the expression of blood PDW,D-D,and miR-223 and the severity and prognosis of children with severe MPP

作　　者：邱潇[1] 董玉斌[1] 曹亚芹[1] QIU Xiao;DONG Yubin;CAO Yaqin(NICU,Zhoukou Central Hospital,Zhoukou,Henan,China,466000)

机构地区：[1]周口市中心医院NICU,河南周口466000

出　　处：《分子诊断与治疗杂志》2025年第2期275-278,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(2021062326)。

摘　　要：目的探讨血小板分布宽度(PDW)、D-二聚体(D-D)、miR-223表达与重症肺炎支原体肺炎(MPP)患儿病情及预后的相关性。方法选取2021年8月至2023年12月周口市中心医院82例重症MPP患儿为重症组,选取同期82例轻症MPP患儿为轻症组。比较两组、重症组患儿不同病程阶段(急性期、恢复期)、不同预后(生存、死亡)PDW、D-D、miR-223表达、临床肺部感染(CPIS)评分,应用Pearson相关性分析PDW、D-D、miR-223表达与重症MPP患儿CPIS评分的相关性,绘制受试者工作特征(ROC)曲线分析PDW、D-D、miR-223单一、联合检测对重症MPP患儿预后死亡的预测价值,采用Logistic回归分析探讨PDW、D-D、miR-223表达与重症MPP患儿预后的关系。结果重症组PDW、D-D、miR-223表达、CPIS评分高于轻症组,差异有统计学意义(P<0.05);重症组急性期PDW、D-D、miR-223表达、CPIS评分高于恢复期,差异有统计学意义(P<0.05);PDW、D-D、miR-223表达与重症MPP患儿CPIS评分呈正相关(P<0.05);重症组死亡患儿PDW、D-D、miR-223表达高于生存患儿,差异有统计学意义(P<0.05);PDW、D-D、miR-223联合检测预测重症MPP患儿预后死亡的AUC值为0.867,对应敏感度为68.75%,特异度为90.91%;PDW、D-D、miR-223水平升高为重症MPP患儿预后死亡的独立危险因素(P<0.05)。结论重症MPP患儿PDW、D-D、miR-223显著升高,且三指标表达水平与病情严重程度及转归明显相关,联合检测上述指标可为临床预测预后提供一定参考。Objective To explore the relationship between blood platelet distribution width(PDW),D-dimer(D-D),and miR-223 expression and the severity of severe mycoplasmal pneumonia pneumonia(MPP)in children,as well as their prognostic value.Methods A total of 82 children with severe MPP at Zhoukou Central Hospital from August 2021 to December 2023 were selected as the severe group,and 82 children with mild MPP in the same period were selected as the mild group.Blood PDW,D-D,miR-223 expression,and clinical pulmonary infection(CPIS)scores were compare between the two groups,the severe group of children with different stages of disease(acute phase,recovery phase),different prognoses(survival,death).Pearson correlation analysis was used to explore the correlation between the expression of various blood indicators and the CPIS score in children with severe MPP.The receiver operating characteristic(ROC)curve was used to assess the predictive value of single and combined detection of blood indicators for the prognosis and mortality of children with severe MPP.Logistic regression analysis was conducted to examine the relationship between the expression of various blood indicators and the prognosis and mortality of children with severe MPP.Results The levels of blood PDW,D-D,miR-223,and CPIS score in the severe group were higher than those in the mild group,and the difference was statistically significant(P<0.05).The levels of blood PDW,D-D,miR-223,and CPIS score in the severe group during the acute phase were higher than those during the recovery phase,and the differences were statistically significant(P<0.05).The levels of blood PDW,D-D,and miR-223 were positively correlated with the CPIS score in children with severe MPP(P<0.05).The levels of blood PDW,D-D,and miR-223 of children who died in the severe group was higher than that of children who survived,and the difference was statistically significant(P<0.05).The AUC value of the combined detection of blood PDW,D-D,and miR-223 for predicting the prognosis and mortality of childre

关 键 词：血小板分布宽度 D-二聚体 miR-223 肺炎支原体肺炎 

分 类 号：R725.6[医药卫生—儿科]