综合早孕期sFlt-1/PLGF比值、血常规、生化指标构建妊娠期高血压疾病预测模型研究  

Study on the construction of a prediction model for hypertensive disorders complicating pregnancy by combining the sFlt-1/PLGF ratio,blood routine and biochemical indicators in early pregnancy

作　　者：侯雪晶[1] 刘陈 齐俊巧[1] 裴梦然 路春梅[1] HOU Xuejing;LIU Chen;QI Junqiao;PEI Mengran;LU Chunmei(Department of Obstetrics,the First Hospital of Qinhuangdao,Qinhuangdao,Hebei,China,066000)

机构地区：[1]秦皇岛市第一医院产科,河北秦皇岛066000

出　　处：《分子诊断与治疗杂志》2025年第2期317-321,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河北省2022年度医学科学研究课题计划项目(2022XT566);秦皇岛市科学技术研究与发展计划项目(201902A048)。

摘　　要：目的通过综合早孕期sFlt-1/PLGF比值、血常规及生化指标,构建妊娠期高血压疾病(HDP)早期预测模型。方法选取2020年6月至2023年12月于秦皇岛市第一医院住院分娩的116名孕妇临床资料,其中35例HDP孕妇作为HDP组,81例非HDP孕妇作为对照组。比较两组实验室相关指标[sFlt-1/PLGF比值、血清铁蛋白(FER)和D-二聚体、血清中纤维蛋白降解产物(FDP)、纤维蛋白原含量(FIb)、白细胞计数(WBC)、中性粒细胞数(NEU)、淋巴细胞数(LYM)、单核细胞数(MONO)、血清糖化血红蛋白(HbA1c)和同型半胱氨酸(Hcy)、血清甘油三酯(TG)、总胆固醇(TC)、尿素、肌酐含量、血糖(FPG)、TyG指数],结合10-折交叉验证,利用早孕期sFlt-1/PLGF比值、血常规及生化指标构建HDP疾病预测模型。结果HDP组sFlt-1/PLGF、WBC、NEU、TG、TC、OGTT结果、D-二聚体及Hcy水平显著高于对照组,LYM低于对照组,差异有统计学意义(P<0.05)。联合sFlt-1/PLGF、WBC、NEU及LYM建立的HDP疾病预测模型,其最大约登指数为0.834,相应敏感度、特异度、AUC分别为87.40%、0.826及85.70%。联合sFlt-1/PLGF、WBC、NEU、LYM、TG、TC、OGTT结果、D-二聚体及Hcy建立的HDP疾病预测模型,其最大约登指数为0.905,相应敏感度、特异度、AUC分别为91.70%、86.90%及0.925。结论综合早孕期sFlt-1/PLGF比值、血常规及生化指标成功构建了HDP早期预测模型,该模型具有较高的预测准确性和可靠性,有助于医生在孕早期即对孕妇行风险评估,从而采取针对性干预措施,降低HDP发生率和并发症风险。Objective To construct an early prediction model for hypertensive disorders complicating pregnancy(HDP)by combining the sFlt-1/PLGF ratio,blood routine and biochemical indicators in early pregnancy.Methods The clinical data of 116 pregnant women who gave birth at the First Hospital of Qinhuangdao from June 2020 to December 2023 were selected.This included 35 HDP pregnant women as the HDP group.81 non-HDP pregnant women were used as the control group.Laboratory-related indicators such as sFlt-1/PLGF ratio,serum ferritin(FER)and D-dimer,serum fibrin degradation product(FDP),fibrinogen content(FIb),white blood cell count(WBC),neutrophil count(NEU),lymphocyte count(LY),monocyte count(MONO),serum glycated hemoglobin(HbA1 c)and homocysteine(Hcy),serum triglyceride(TG),total cholesterol(TC),urea,creatinine content,blood glucose(FPG),TyG index were compared between the two groups,using 10-fold cross-validation.A prediction model for HDP disease was constructed using the sFlt-1/PLGF ratio,blood routine and biochemical indicators in early pregnancy.Results The levels of sFlt-1/PLGF,WBC,NEU,TG,TC,OGTT results,D-dimer,and Hcy in the HDP group were significantly higher than those in the control group,and LYM was lower than that in the control group(P<0.05).The HDP disease prediction model established by combining sFlt-1/PLGF,WBC,NEU,and LYM had a maximum Youden in-dex of 0.834,and the corresponding sensitivity,specificity and AUC were 87.40%,0.826 and 85.70%,respectively.The HDP disease prediction model established by combining sFlt-1/PLGF,WBC,NEU,LYM,TG,TC,OGTT results,D-dimer,and Hcy had a maximum Youden index of 0.905,with corresponding sensitivity,specificity and AUC of 91.70%,86.90%,and 0.925,respectively.Conclusion The early prediction model for HDP was successfully constructed by combining the sFlt-1/PLGF ratio,blood routine and biochemical indicators in early pregnancy.This model demonstrates high prediction accuracy and reliability,making it helpful for doctors to evaluate the risk of pregnant women in early pregnanc

关 键 词：早孕期 sFlt-1PLGF比值 血常规 生化指标 妊娠期高血压疾病 

分 类 号：R714.246[医药卫生—妇产科学]