血清IL-6、ET-1及sCD206对儿童重症支原体肺炎治疗疗效的预测作用  

Predictive effect of serum IL-6,ET-1 and sCD206 on the therapeutic efficacy of severe mycoplasma pneumonia in children

作　　者：董倩[1] 李娜[1] 于光志 陈娟[1] 杨琳[1] DONG Qian;LI Na;YU Guangzhi;CHEN Juan;YANG Lin(Department of Pediatrics,the Affiliated Hospital of Jining Medical College,Jining,Shandong,China,272100)

机构地区：[1]济宁医学院附属医院儿科,山东济宁272100

出　　处：《分子诊断与治疗杂志》2025年第2期322-325,共4页Journal of Molecular Diagnostics and Therapy

基　　金：山东省中医药科技项目(M-2022243);济宁市重点研发计划项目(2022YXNS167)。

摘　　要：目的探讨血清白介素-6(IL-6)、内皮素-1(ET-1)及可溶性甘露糖受体(sCD206)对儿童重症支原体肺炎(SMPP)治疗疗效的预测作用。方法选取2023年1月-2023年12月济宁医学院附属医院儿科收治的SMPP患儿200例为研究对象。比较SMPP患儿治疗前、治疗后IL-6、ET-1、sCD206水平;统计所有患儿治疗结果;分析影响SMPP患儿治疗疗效的单因素及多因素;计算IL-6、ET-1、sCD206单独及联合对SMPP患儿治疗疗效的预测价值。结果SMPP患儿治疗后的血清IL-6、ET-1、sCD206水平均低于治疗前,差异有统计学意义(P<0.05)。200例SMPP患儿经治疗后,治疗显效41例(20.50%),治疗有效139例(69.50%),治疗无效20例(10.00%)。将治疗显效与有效纳为有效组(n=180),将治疗无效纳入为无效组(n=20)。治疗有效组与无效组性别、年龄、CPIS分级等一般资料比较,差异无统计学意义(P>0.05);有效组血清IL-6、ET-1、sCD206水平低于无效组,差异有统计学意义(P<0.05)。经二元Logistic回归分析结果显示:IL-6、ET-1、sCD206水平升高均是影响SMPP患儿治疗疗效的危险因素(P<0.05)。IL-6、ET-1、sCD206联合预测SMPP患儿治疗疗效的AUC为0.916,敏感度、特异度分别为95.00%、94.11%,高于三指标单独检测(P<0.05)。结论IL-6、ET-1、sCD206对SMPP患儿经大环内酯类药物治疗的临床疗效具有重要的参考价值,可为制定临床治疗方案提供一定依据。Objective To investigate the predictive effect of serum interleukin-6(IL-6),endothelin-1(ET-1)and soluble mannose receptor(sCD206)on the treatment of severe mycoplasma pneumoniae pneumonia(SMPP)in children.Methods A total of 200 children with SMPP admitted to the Department of Pediatrics,at the Affiliated Hospital of Jining Medical College from January 2023 to December 2023 were selected as the study subjects.The levels of IL-6,ET-1,and sCD206 in children with SMPP before and after treatment were compared.The treatment results of all children were counted.The single factor and multiple factors affecting the therapeutic effect of SMPP children were analyzed.The predictive value of IL-6,ET-1,and sCD206 alone and in combination for the treatment of SMPP was calculated.Results The levels of serum IL-6,ET-1,and sCD206 in children with SMPP after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,41 cases(20.50%)were markedly effective,139 cases(69.50%)were effective,and 20 cases(10.00%)were ineffective.The markedly effective and effective treatments were included in the effective group(n=180),and the ineffective treatment was included in the ineffective group(n=20).There was no significant difference in gender,age,CPIS classification and other general data between the effective group and the ineffective group(P>0.05).The levels of serum IL-6,ET-1,and sCD206 in the effective group were lower than those in the ineffective group,and the differences were statistically significant(P<0.05).The results of binary logistic regression analysis showed that the increase in IL-6,ET-1,and sCD206 levels were all risk factors affecting the therapeutic effect of SMPP children(P<0.05).The AUC of IL-6,ET-1,and sCD206 in predicting the therapeutic effect of SMPP children was 0.916,with a sensitivity and specificity of 95.00%and 94.11%,respectively,which were higher than those of the three indicators alone(P<0.05).Conclusion IL-6,ET-1,and sCD206 have significant refe

关 键 词：IL-6 ET-1 sCD206 重症支原体肺炎 

分 类 号：R72[医药卫生—儿科]