One-year clinical events according to frailty in older patients with non-ST elevation acute coronary syndrome undergoing coronary angiography:an analysis of the IMPACT-TIMINGGO study  

作　　者：Pablo Díez-Villanueva Pedro Cepas-Guillén María Thiscal López Lluva Alfonso Jurado-Román Pablo Bazal-Chacón Martín Negreira-Caamaño Iván Olavarri-Miguel Ane Elorriaga Ricardo Rivera-López David Escribano Pablo Salinas María Martínez-Avial Antonio Martínez-Guisado Clea González-Maniega Felipe Díez-Delhoyo 

机构地区：[1]Servicio de Cardiología,Hospital Universitario de La Princesa,Madrid,Spain [2]Servicio de Cardiología,Hospital Clinic,Barcelona,Spain [3]Servicio de Cardiología,Hospital Universitario de León,León,Spain [4]Servicio de Cardiología,Hospital La Paz,Madrid,España IdiPaz(Instituto de Investigación Sanitaria del Hospital Universitario La Paz).Madrid,Spain [5]Servicio de Cardiología,Complejo Hospitalario de Navarra,Pamplona,Navarra,Spain [6]Servicio de Cardiología,Hospital Universitario,Octubre,Madrid,Spain [7]Servicio de Cardiología,Hospital Marqués de Valdecilla,Santander,Cantabria,Spain [8]Servicio de Cardiología,Hospital Universitario de Basurto,Bilbao,Vizcaya,Spain [9]Servicio de Cardiología,Hospital Virgen de las Nieves,Granada,Spain [10]Servicio de Cardiología,Hospital Universitario San Juan de Alicante,San Juan de Alicante,Spain [11]Servicio de Cardiología,Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC),Madrid,Spain

出　　处：《Journal of Geriatric Cardiology》2025年第1期159-168,共10页老年心脏病学杂志(英文版)

摘　　要：Objective To evaluate the prevalence and one-year prognosis associated with frailty in a contemporary cohort of older patients with non-ST-elevation acute coronary syndrome(NSTEACS).Methods The IMPACT-TIMING-GO registry(IMPACT of Time of Intervention in patients with Myocardial Infarction with Non-ST seGment elevation.ManaGement and Outcomes)prospectively included 1020 patients with NSTEACS undergoing invasive coronary angiography between April and May 2021.For this sub-study,patients≥65 years were selected.Frailty was assessed according to FRAIL scale.We studied all-cause mortality and the composite of all-cause mortality or all-cause hospitalizations at one-year follow-up after discharge.Results Five hundred and sixty seven patients(mean age:75.8±6.7 years,28.2%women)were included:316(55.7%)were robust,183(32.3%)prefrail,and 68(12.0%)frail.Frail patients were significantly older,more often women,and presented a worse baseline clinical profile.There were no differences among groups regarding pretreatment with a P2Y12 inhibitor.An urgent angiography(<24 h)was less frequently performed in frail patients,with no differences regarding revascularization approach or in main in-hospital adverse events,although acute kidney disease occurred more frequently in frail patients.At 1-year follow-up,20 patients died(3.6%).Chronic kidney disease was independently associated with 1-year all-cause death,although a trend towards higher mortality was observed in frail patients(HR=3.01;95%CI:0.93-9.78;P=0.065).Frailty was independently associated with higher 1-year all-cause mortality or all-cause rehospitalizations(HR=2.23;95%CI:1.43-3.46;P<0.001)Conclusions In older patients with NSTEACS,frailty independently associates higher all-cause mortality or all-cause hospital admissions at one-year follow-up.

关 键 词：patients CORONARY ANGIOGRAPHY 

分 类 号：R54[医药卫生—心血管疾病]