周围神经损伤领域组织工程技术应用的研究热点与趋势变化  

Research hotspots and trends in application of tissue engineering in peripheral nerve injury

作　　者：赵晓璇 刘帅祎 邢政 李庆雯[1] 褚晓蕾[2] 李奇[2] Zhao Xiaoxuan;Liu Shuaiyi;Xing Zheng;Li Qingwen;Chu Xiaolei;Li Qi(Tianjin Key Laboratory of Sports Physiology and Sports Medicine,College of Exercise&Health,Tianjin University of Sport,Tianjin 301617,China;Tianjin Hospital,Tianjin 300211,China)

机构地区：[1]天津体育学院运动健康学院天津市运动生理学与运动医学重点实验室,天津市301617 [2]天津市天津医院,天津市300211

出　　处：《中国组织工程研究》2025年第30期6591-6600,共10页Chinese Journal of Tissue Engineering Research

基　　金：天津市自然科学基金面上项目(22JCYBJC00220),项目负责人:褚晓蕾;天津市自然科学基金面上项目(22JCYBJC00210),项目负责人:李奇;国家重点研发计划“生物与信息融合(BT与IT融合)”重点专项项目(2023YFF1205200),项目参与人:邢政。

摘　　要：背景:周围神经损伤会对患者造成不同程度的功能障碍,并且长节段周围神经缺损的修复重建缺乏有效的治疗手段。近年来,组织工程学逐渐应用于长节段周围神经缺损的修复中,但研究的热点与发展动态不明。目的:使用文献计量学软件分析近20年来国内外在周围神经组织工程学的研究热点和趋势变化。方法:使用CiteSpace 6.2R6软件对Web of Science数据库和中国知网中2004-2024年发表的周围神经组织工程学文献进行高被引分析和关键词分析,其中关键词分析包括关键词共现分析、关键词聚类分析、关键词时间轴分析和关键词突现分析。结果与结论:从Web of Science数据库和中国知网中各纳入了2961和1171篇文献,Web of Science数据库该领域的发文量存在波动但呈现逐年递增的趋势,中国知网该领域的发文量每年相差不大。Web of Science数据库中该领域引用前10的文献大多为综述型文章。结合Web of Science数据库和中国知网关键词分析结果,发现近20年来研究较多的神经组织工程学材料包括丝素蛋白、胶原蛋白、壳聚糖、聚己内酯、聚乳酸、石墨烯等,研究较多材料中的生化线索包括嗅鞘细胞、施万细胞、干细胞、神经生长因子等,引入外部物理因子使用最多的是在材料中施加电刺激,神经组织工程学技术研究较多的是静电纺丝技术和3D打印技术。BACKGROUND:Peripheral nerve injuries can cause severe functional disabilities in patients,and long-segment nerve defects often fail to regenerate spontaneously.In recent years,tissue engineering techniques have gradually been applied to the repair of long-segment nerve injuries,yet research hotspots and development trends are unclear.OBJECTIVE:To analyze the research hotspots and trends in the field of peripheral nerve tissue engineering over the past 20 years using bibliometric software.METHODS:CiteSpace 6.2R6 software was employed to conduct highly cited analysis and keyword analysis on peripheral nerve tissue engineering literature published from 2004 to 2024 in the Web of Science and China National Knowledge Infrastructure(CNKI)databases.The keyword analysis encompasses keyword co-occurrence analysis,keyword clustering analysis,keyword timeline analysis,and keyword emergence analysis.RESULTS AND CONCLUSION:A total of 2961 articles from the Web of Science database and 1171 articles from the CNKI database were included.The number of publications in the Web of Science database showed fluctuations but exhibited an overall increasing trend year by year,while the publication volume in the CNKI database remained relatively stable annually.Most of the top ten most cited articles in the Web of Science database were review articles.The results of the keyword analysis from Web of Science and CNKI databases indicated that the most studied nerve tissue engineering materials over the past 20 years include silk fibroin,collagen,chitosan,polycaprolactone,polylactic acid,and graphene.The biochemical cues investigated in these materials include olfactory ensheathing cells,Schwann cells,stem cells,and nerve growth factors.The most commonly employed external physical factor is electrical stimulation applied to the materials.Among various tissue engineering techniques,electrospinning technology and 3D printing technology have been the most extensively researched.

关 键 词：周围神经损伤 可视化分析 组织工程 神经导管 神经支架 施万细胞 干细胞 3D打印技术 工程化组织构建 

分 类 号：R459.9[医药卫生—治疗学] R319[医药卫生—临床医学] R651