孟德尔随机化研究类风湿性关节炎与多囊卵巢综合征的因果关系  

Mendelian Randomization Study on the Causal Relationship between Rheumatoid Arthritis and Polycystic Ovary Syndrome

作　　者：李文倩[1] 魏欣妍 王滢莹 单红英[1] LI Wen-qian;WEI Xin-yan;WANG Ying-ying;SHAN Hong-ying(Department of Reproductive Medicine,the First Affiliated Hospital of Shihezi University,Xinjiang Shihezi,832008)

机构地区：[1]石河子大学第一附属医院生殖医学科,新疆石河子832008

出　　处：《农垦医学》2024年第6期516-519,559,共5页Journal of Nongken Medicine

基　　金：石河子大学校级科研项目(ZZZC202062A)。

摘　　要：目的:本研究运用两样本双向孟德尔随机化(Mendelian Randomization,MR)方法探究类风湿性关节炎(Rheumatoid Arthritis,RA)和多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)之间发病的因果关系。方法:从IEU open GWAS数据库和FinnGen数据库中获取RA和PCOS相关的单核苷酸多态性(Single Nucleotide Polymorphisms,SNP)信息。选取与两病种强相关的SNP作为工具变量,运用5种MR分析方法进行双向MR分析,并对结果进行敏感性检验。结果:逆方差加权法(Inverse Variance Weighted,IVW)方法的正向MR分析表明RA与PCOS之间存在正向的因果关联(OR=1.069,95%CI:1.005-1.136,P=0.033),在除简单模型法外的其他方法中得到一致的结论;反向MR分析则表明PCOS对RA的发病没有显著影响(P>0.05);敏感性检验表明,分析结果具有稳健性,工具变量未发现水平多效性。结论:RA与PCOS之间可能存在单向的因果关联,其中RA可能是PCOS发病的危险因素。Objective:This study investigated the causal relationship between the pathogenesis of rheumatoid arthritis(RA)and polycystic ovary syndrome(PCOS)using two-sample bidirectional Mendelian randomization(MR).Methods:Single nucleotide polymorphisms(SNP)information related to RA and PCOS was obtained from the IEU open GWAS database and FinnGen database.SNPs strongly associated with the two diseases were selected as instrumental variables,and five MR analysis methods were applied to perform two-way MR analysis,and sensitivity tests were performed on the results.Results:Forward MR analysis by the inverse variance weighted(IVW)method indicated a positive causal association between RA and PCOS(OR=1.069,95%CI:1.005-1.136,P=0.033).Consistent findings were obtained in methods other than the simple modelling approach.Reverse MR analysis,on the other hand,showed no significant effect of PCOS on the development of RA(P>0.05).Sensitivity tests showed that the analyses were robust and no horizontal pleiotropy was found for the instrumental variables.Conclusions:There may be a unidirectional causal association between RA and PCOS,in which RA may be a risk factor for the development of PCOS.

关 键 词：类风湿性关节炎 多囊卵巢综合征 孟德尔随机化 因果关系 

分 类 号：R593.22[医药卫生—内科学] R711.75[医药卫生—临床医学]