银屑病患者血清VDR,FGF23表达水平与中医证型及病情的相关性  

Correlation Between Serum VDR,FGF23 Expression Level and TCM Syndrome Type and Disease of Patients with Psoriasis

作　　者：杜凡 郭慧敏 张辉[1] DU Fan;GUO Huimin;ZHANG Hui(Department of Dermatology,Yan′an University Affiliated Hospital,Yan′an 716000,China;Department of Dermatology,Yan′an Traditional Chinese Medicine Hospital,Yan′an 716000,China)

机构地区：[1]延安大学附属医院皮肤科,陕西延安716000 [2]延安市中医医院皮肤科,陕西延安716000

出　　处：《皮肤科学通报》2025年第1期69-73,共5页Dermatology Bulletin

基　　金：陕西省自然科学基金项目(2021JM-564)。

摘　　要：目的分析银屑病患者血清维生素D受体(vitamin D receptor,VDR),成纤维细胞生长因子23(fibroblast growth factor 23,FGF23)水平与患者病情严重程度以及中医证型的相关性。方法选取2020年1月—2020年12月期间延安大学附属医院皮肤科确诊的118例寻常型银屑病患者,将其分为血热证(38例)、血瘀证(36例)和血燥证(44例),另选同期健康者42例与患者作为对照组。酶联免疫吸附法检测血清细胞因子表达,Pearson法分析相关性。结果3种不同证型患者病程、银屑病皮损面积和严重程度指数(psoriasis lesion area and severity index,PASI)评分比较差异无统计学意义(P>0.05);与对照组相比,银屑病患者血清VDR水平降低[(14.32±3.71)ng/mL vs.(19.28±4.38)ng/mL],FGF23水平升高[(79.85±11.52)ng/L vs.(60.32±10.30)ng/L](t=7.087,9.691;P均<0.05);与血热证相比,血瘀证、血燥证VDR水平升高[(15.41±3.61)ng/mL vs.(15.24±3.62)ng/mL vs.(12.19±3.94)ng/mL],FGF23水平降低[(72.94±13.35)ng/L vs.(80.35±11.64)ng/L vs.(86.38±11.51)ng/L](F=9.207,16.155;P均<0.05);与血瘀证相比,血燥证FGF23水平降低(q=3.801,P<0.05);银屑病患者血清VDR水平与PASI评分负相关(r=-0.842,P<0.05);血清FGF23水平与PASI评分正相关(r=0.817,P<0.05)。结论银屑病患者血清VDR水平降低,FGF23水平升高,二者与患者的疾病严重程度和中医分型有关。Objective To analyze the correlation between serum vitamin D receptor(VDR)and fibroblast growth factor 23(FGF23)levels and the severity of the disease and TCM syndrome types of patients with psoriasis.Methods A total of 118 patients with psoriasis vulgaris diagnosed in the dermatology department of the Affiliated Hospital of Yan′an University from January 2020 to December 2020 were selected,and they were divided into blood heat syndrome,blood stasis syndrome and blood dryness syndrome(38 cases,36 cases,44 cases,respectively).42 healthy patients were selected for control during the same period and named as control group.Serum factor expression was detected by enzyme-linked immunosorbent assay(ELISA)and correlation was analyzed by Pearson method.Results There was no significant difference in the course of disease and psoriasis lesion area and severity index(PASI)score among patients with psoriasis of blood heat syndrome,blood stasis syndrome and blood dryness syndrome(P>0.05);Compared with the control group,the serum VDR level in patients with psoriasis was significantly lower[(14.32±3.71)ng/mL vs.(19.28±4.38)ng/mL],and the FGF23 level was significantly higher[(79.85±11.52)ng/L vs.(60.32±10.30)ng/L],t=7.087,9.691;both P<0.05;compared with the blood-heat syndrome,the VDR level in patients with blood-stasis syndrome and blood-drying syndrome was significantly higher[(15.41±3.61)ng/mL vs.(15.24±3.62)ng/mL vs.(12.19±3.94)ng/mL],and the FGF23 level was significantly lower[(72.94±13.35)ng/L vs.(80.35±11.64)ng/L vs.(86.38±11.51)ng/L](F=9.207,16.155;both P<0.05);compared with blood stasis syndrome,the level of FGF23 in blood dryness syndrome decreased(q=3.801,P<0.05);the level of serum VDR in psoriasis patients was negatively correlated with PASI score(r=-0.842,P<0.05);the level of serum FGF23 was positively correlated with PASI score(r=0.817,P<0.05).Conclusion The level of serum VDR in psoriasis patients is decreased,and the FGF23 level is increased,both of them are related to the disease severity and TCM clas

关 键 词：银屑病 维生素D受体 成纤维细胞生长因子23 中医证型 

分 类 号：R751[医药卫生—皮肤病学与性病学]