线粒体质量控制失衡对创伤后器官功能障碍影响的研究进展  

Impact of mitochondrial quality control imbalance on post‑traumatic organ dysfunction:a review

作　　者：陆安静 陆元兰 刘静 王瑞烈 杨光 吴瑾 王树洪 梁昌强 Lu Anjing;Lu Yuanlan;Liu Jing;Wang Ruilie;Yang Guang;Wu Jin;Wang Shuhong;Liang Changqiang(Department of Emergency,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China;Surgery Room,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)

机构地区：[1]遵义医科大学附属医院急诊科,遵义563003 [2]遵义医科大学附属医院手术室,遵义563003

出　　处：《中华创伤杂志》2025年第2期212-218,共7页Chinese Journal of Trauma

基　　金：国家自然科学基金(82460385);贵州省临床专项[黔科合成果‑LC(2024)074]。

摘　　要：创伤可引起机体内环境紊乱,导致器官功能障碍,表现为急性呼吸窘迫、肝肾功能异常、循环系统障碍和神经系统损伤等。线粒体质量控制(MQC)包括自噬、动力学变化和生成等过程,对维持线粒体功能至关重要。而创伤后的应激反应可导致线粒体功能障碍和MQC失衡,加剧器官损伤,而纠正MQC失衡有助于改善器官功能障碍。目前关于MQC在创伤后器官功能障碍的研究多局限于MQC中某一机制的失衡,缺乏对其发生发展的系统性认识。为此,笔者就MQC失衡对创伤后器官功能障碍影响的研究进展进行综述,为临床治疗提供参考。Trauma can disrupt the body′s internal environment,resulting in organ dysfunction.This may manifest as symptoms such as acute respiratory distress,liver and kidney dysfunction,circulatory disorders and neurological damage.Mitochondrial quality control(MQC),encompassing processes like autophagy,dynamic changes,and biogenesis,plays an essential role in maintaining mitochondrial function.Stress responses following trauma can cause mitochondrial dysfunction and MQC imbalance,thereby exacerbating organ injury.Correcting MQC imbalance can improve organ function.Current researches on MQC in post‑traumatic organ dysfunction mainly focuses on imbalance in specific MQC mechanism,lacking a systemic understanding of its incidence and progression.To this end,the authors reviewed the progress in researches on the impact of MQC imbalance on post‑traumatic organ dysfunction,aiming to provide insights for clinical treatment.

关 键 词：创伤和损伤 多器官功能衰竭 线粒体 

分 类 号：R641[医药卫生—外科学]