德宏傣族景颇族自治州2004-2021年报告丙型肝炎病例感染及抗病毒治疗状况  

Infection and antiviral therapy status of hepatitis C cases reported in Dehong Dai and Jingpo Autonomous Prefectures from 2004 to 2021

作　　者：周群博 唐仁海[1] 冯兴美 杨跃诚[1] 叶润华[1] 龚渝蓉[1] 师乃丽 谢喜梅 王龙钦 许所菊 刘英[6] 何纳[7] 丁盈盈[7] 段松[1] ZHOU Qunbo;TANG Renhai;FENG Xingmei;YANG Yuecheng;YE Runhua;GONG Yurong;SHI Naili;XIE Ximei;WANG Longqin;XU Suoju;LIU Ying;HE Na;DING Yingying;DUAN Song(Department of AIDS/STD Prevention and Control,Dehong Prefecture Center for Disease Control and Prevention,Mangshi 678400,Yunnan,China;Department of AIDS/STD Prevention and Control,Mangshi Center for Disease Control and Prevention of Dehong Prefecture,Mangshi 678400,Yunnan,China;Department of AIDS/STD Prevention and Control,Ruili City Center for Disease Control and Prevention of Dehong Prefecture,Ruili 678600,Yunnan,China;Department of AIDS/STD Prevention and Control,Yingjiang County Center for Disease Control and Prevention of Dehong Prefecture,Yingjiang 679300,Yunnan,China;Department of AIDS/STD Prevention and Control,Longchuan County Center for Disease Control and Prevention of Dehong Prefecture,Longchuan 678700,Yunnan,China;Department of AIDS/STD Prevention and Control,Lianghe County Center for Disease Control and Prevention of Dehong Prefecture,Lianghe 679200,Yunnan,China;Department of Epidemiology,School of Public Health,Fudan University Key Laboratory of Public Health Safety of Ministry of Education,Shanghai 200032,China)

机构地区：[1]德宏州疾病预防控制中心艾滋病性病防制科,云南芒市678400 [2]德宏州芒市疾病预防控制中心艾滋病性病防制科,云南芒市678400 [3]德宏州瑞丽市疾病预防控制中心艾滋病性病防制科,云南瑞丽678600 [4]德宏州盈江县疾病预防控制中心艾滋病性病防制科,云南盈江679300 [5]德宏州陇川县疾病预防控制中心艾滋病性病防制科,云南陇川678700 [6]德宏州梁河县疾病预防控制中心艾滋病性病防制科,云南梁河679200 [7]复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室,上海200032

出　　处：《中国艾滋病性病》2025年第2期161-166,共6页Chinese Journal of Aids & STD

基　　金：国家重点地区艾滋病防治项目(卫办疾控发[2004]49号);国家科技重大专项(2018ZX10715006-001)。

摘　　要：目的 了解德宏傣族景颇族自治州(简称“德宏州”)既往报告丙肝病例的现症感染及抗病毒治疗情况,为制定完善丙肝防治策略提供参考依据。方法 通过“中国疾病预防控制信息系统”下载录入日期为2004年1月1日-2021年12月31日的已审核现住址为德宏州的既往报告丙肝病例资料,通过对既往病例资料进行梳理确定研究对象,于2022年7月至2023年12月对符合条件的研究对象进行随访调查,内容包括研究对象的人口学特征、丙肝防治知识、既往诊疗情况等,并抽取静脉血5 mL进行丙肝病毒核酸(HCV-RNA)检测。采用Logistic回归模型分析既往感染和抗病毒治疗相关因素。结果 3 003例研究对象中,HCV-RNA阳性1 898例(63.2%),多因素Logistic回归分析结果显示:男性、职业为农民或民工、文化程度为文盲/小学、婚姻状况为未婚/离异或丧偶、丙肝报告年份为2013-2021年、不知道自己感染丙肝、有共用针具吸毒史、有商业性行为史、有在街头或小店等非正规医疗机构进行过损伤性美容或治疗经历史者的HCV-RNA阳性风险更高。知晓自身感染状况的1 444例确诊病例中,456例(31.6%)既往接受过抗病毒治疗,多因素Logistic回归分析结果显示:中国籍、女性、职业为其他、受教育程度为初中及以上、已婚、月均收入>3 000元、知晓丙肝知识的研究对象更容易接受抗病毒治疗。结论 德宏州随访调查既往丙肝病例的HCVRNA阳性率高,需有针对性地强化对既往丙肝患者的随访与宣传教育,提升丙肝预防及治疗知识的知晓率,促进主动检测和及时规范抗病毒治疗,同时扩大丙肝核酸检测覆盖率,加强转介和动员治疗,提高治疗覆盖率。Objective To understand the infection status and antiviral treatment of previously reported hepatitis C cases in Dehong Dai and Jingpo Autonomous Prefectures(referred to as"Dehong Prefecture"),and to provide a reference for formulating and improving hepatitis C prevention and control strategies.Methods Data of previously reported hepatitis C cases in Dehong Prefecture from January 1,2004,to December 31,2021,which have been audited were obtained from the China Disease Prevention and Control Information System.On-site investigations were conducted with eligible participants with contact information from July 2022 to December 2023.Data on demographic characteristics,knowledge of HCV prevention and treatment,and previous diagnoses and treatments were obtained.A 5 mL venous blood sample was extracted for hepatitis C virus nucleic acid(HCV-RNA)testing.Logistic regression models were used to analyze factors related to current symptomatic infection and antiviral treatment.Results Among 3003 participants,1898(63.2%)were HCV-RNA-positive.Multivariate logistic regression analysis showed that males,those with occupations such as farmers or migrant workers,those with an educational level of illiterate/primary school,those with unmarried/divorced/widowed marital statuses,those who reported hepatitis C infection between 2013 and 2021,those who were unaware of their hepatitis C infection,those with a history of sharing needles for drug use,those with a history of commercial sexual behavior,and those with a history of invasive beauty or treatment procedures at informal medical institutions such as street stalls or small shops had a higher risk of being HCV-RNA positive.Among the 1444 confirmed cases aware of their infection status,456(31.6%)had previously received antiviral treatment.Participants who were Chinese nationals,female,had occupations other than farming or migrant workers,had an educational level of junior high school or above,were married,had a monthly income of more than 3000 yuan,and were knowledgeable regarding hep

关 键 词：丙型肝炎 既往报告 流行特征 抗病毒治疗 

分 类 号：R512.6[医药卫生—内科学]