肠道菌群在HIV相关高脂血症中的作用  

Role of the gut microbiota in HIV-associated hyperlipidemia

作　　者：周雪倩 岳静宇[1,2,3] 张柳婧 赵扬 刘凯新 徐立然 ZHOU Xueqian;YUE Jingyu;ZHANG Liujing;ZHAO Yang;LIU Kaixin;XU Liran(AIDS Clinical Research Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;Henan Provincial Key Laboratory of Traditional Chinese Medicine Prevention and Treatment of Viral Diseases,Zhengzhou 450000,Henan,China;Henan Provincial Collaborative Innovation Center for R&D of the Whole Industry Chain of Yu Medicine,Zhengzhou 450046,Henan,China)

机构地区：[1]河南中医药大学第一附属医院艾滋病临床研究中心,郑州450000 [2]河南中医药大学第一临床医学院,郑州450000 [3]河南省病毒性疾病中医药防治重点实验室,郑州450000 [4]豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《中国艾滋病性病》2025年第2期221-224,F0003,共5页Chinese Journal of Aids & STD

基　　金：河南省重点研发与推广专项课题(232102311222);河南省病毒性疾病中医药防治重点实验室开放基金课题(SBDSYY2021-002,SBDSYY2022-002);河南省中医药科学研究专项课题(2019 JDZX2043)。

摘　　要：在HIV/AIDS患者中,由于HIV侵袭、cART的应用以及免疫炎症反应等多重因素的共同作用,常引发内分泌系统、骨骼系统、心血管系统以及精神系统等多方面的疾病。其中,高脂血症作为一种常见的HIV/AIDS并发症,显著提高了心血管疾病的风险,不仅严重损害了HIV患者的生活质量,也给社会带来了重大的负担。尽管目前HIV相关高脂血症的确切发病机制尚不完全清晰,但已有研究指出,肠道菌群失调是诱发高脂血症发病机制的一个重要因素,且HIV感染者的肠道菌群确实存在显著失衡现象。基于此,本文对HIV/AIDS患者的肠道菌群失调引发高脂血症的发病机制及其相关治疗进行阐述,旨在探索HIV/AIDS相关高脂血症的预防与治疗的新策略。In patients with HIV/AIDS,owing to the combined effect of multiple factors,such as HIV viral invasion,the use of combined antiretroviral therapy(cART)and the immune inflammatory response often leads to diseases of the endocrine,skeletal,cardiovascular,and mental systems.Hyperlipidemia,a common complication of HIV/AIDS,significantly increases the risk of cardiovascular disease,which not only seriously impairs the quality of life of patients with HIV,but also causes a significant burden to society.Although the exact pathogenesis of HIV-associated hyperlipidemia is unclear,some studies have emphasized intestinal dysbiosis as an important factor in the pathogenesis of hyperlipidemia,and confirmed a significant imbalance in the intestinal microbiota of patients with HIV.This study elaborates on the pathogenesis of hyperlipidemia caused by intestinal dysbiosis in patients with HIV/AIDS and its related treatments,aiming to explore new strategies for the prevention and treatment of HIV/AIDS-related hyperlipidemia.

关 键 词：艾滋病病毒感染者/艾滋病患者 高脂血症 肠道菌群 发病机制 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]