冻融周期单胚胎移植后单卵双胎的相关因素分析  

Analysis of factors associated with monozygotic twin after single Frozen-thaw embryo transfer

作　　者：张珺 赵捷 黄铄[1] Zhang Jun;Zhao Jie;Huang Shuo(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital),Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education,Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,State Key Laboratory of Female Fertility Promotion,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191)

机构地区：[1]北京大学第三医院妇产科生殖医学中心,国家妇产疾病临床医学研究中心(北京大学第三医院),辅助生殖教育部重点实验室(北京大学),北京市生殖内分泌与辅助生殖技术重点实验室,女性生育力促进全国重点实验室,北京100191

出　　处：《现代妇产科进展》2025年第3期207-210,216,共5页Progress in Obstetrics and Gynecology

基　　金：国家自然科学基金(No:82271863);北京大学第三医院院临床重点项目(No:BYSYZD2023007)。

摘　　要：目的:探讨经辅助生殖技术单胚胎移植后发生单卵双胎(MZT)的相关因素。方法:回顾性分析2010年1月至2023年6月在北京大学第三医院生殖医学中心行冻融周期单胚胎移植后共24585例临床妊娠患者的基本资料,其中MZT 409例,以1∶4比例按照移植日期匹配单胎1636例,分析两组患者基本特征、移植方案和不同的实验室操作与发生MZT的相关性。结果:MZT发生率为1.7%(409/24585)。单因素分析显示,MZT组母亲体质量指数(BMI)高于单胎组[22.00(20.10~24.70)vs 21.51(19.60~24.22),P=0.007]。回归分析显示,母亲BMI与MZT发生显著相关(OR=0.928,95%CI:0.904~0.954),而移植方案、受精方式、是否进行辅助孵化(AH)、是否行胚胎着床前遗传学检测(PGT)、胚胎移植类型等在两组间没有差异。结论:冻融周期单胚胎移植后单卵双胎的发生与移植方案、卵细胞浆内单精子注射、AH、PGT、囊胚培养等医源操作无显著关联。Objective:To analyze the incidence and the factors relevant to monozygotic twins(MZT)pregnancy conceived by assisted reproductive technology(ART)after frozen-thaw single embryo transfer.Methods:A retrospective analysis was conducted on the basic data of 24585 patients who got pregnancy after frozen-thawed single embryo transfer treatment at the Reproductive Medicine Center of Peking University Third Hospital between January 2010 and June 2023.Among these,409 cases were monozygotic twin(MZT)pregnancies.The MZT group was matched with a singleton group(1∶4 ratio)based on the transfer date,resulting in 1636 singleton cases.The study analyzed the basic characteristics,treatment protocols,and laboratory procedures in both groups to explore their association with the occurrence of MZT.Results:409 cases were MZT pregnancies(1.7%,409/24585).In the univariate analysis,there was a statistically significant difference in maternal body mass index(BMI)between the MZT group and the singleton pregnancy group[22.00(20.10~24.70)vs 21.51(19.60~24.22),P=0.007].The regression analysis revealed that maternal BMI was significantly associated with the occurrence of MZT(OR=0.928,95%CI:0.904~0.954).However,no significant differences were observed between the two groups in terms of treatment protocols,fertilization methods,assisted hatching(AH),preimplantation genetic testing(PGT),or the type of embryo transfer.Conclusion:The occurrence of MZT after frozen-thawed single embryo transfer is not significantly associated with medical procedures,including treatment protocols,intracytoplasmic sperm injection(ICSI),AH,PGT,or blastocyst culture.

关 键 词：辅助生殖技术 体外受精 卵细胞浆内单精子注射 单卵双胎 冻融胚胎移植 辅助孵化 

分 类 号：R711[医药卫生—妇产科学]