腹部常温区域机械灌注在以循环标准判定死亡的遗体器官捐献中的临床应用专家共识  

Consensus on clinical application of normothermic regional perfusion in donation after circulatory determination of death

作　　者：中华医学会器官移植学分会 何晓顺[2] 郭志勇[2] 张嘉懿 王铁龙 王彦峰[4] 欧阳青 张波[6] 孙强 孙纪三[8] 廖吉祥 潘崎[10] 廖苑[3] Branch of Organ Transplantation of Chinese Medical Association;He Xiaoshun;Guo Zhiyong(不详;Organ Transplant Center,the First Affiliated Hospital,Sun Yat-sen University,Guangzhou 510062,China)

机构地区：[1]不详 [2]中山大学附属第一医院器官移植中心,广州510062 [3]中山大学附属第一医院 [4]武汉大学中南医院 [5]中国人民解放军南部战区总医院 [6]华中科技大学同济医学院附属同济医院 [7]浙江大学医学院附属第二医院 [8]天津市第一中心医院 [9]广西医科大学第二附属医院 [10]中国医科大学附属第一医院

出　　处：《中华移植杂志(电子版)》2024年第6期386-397,共12页Chinese Journal of Transplantation(Electronic Edition)

基　　金：中国器官移植发展基金会科研项目国家卫生健康委员会医疗应急司政府购买服务国家自然科学基金面上项目(81970564,82070670,82170663,82370664,82300744)。

摘　　要：器官移植是治疗终末期器官疾病的最有效方法。器官短缺是器官移植领域面临的主要挑战之一。为此,临床上越来越多地使用包括以循环标准判定死亡的遗体器官捐献(DCDD)在内的扩大标准供者器官。然而,DCDD供器官因遭受额外的热缺血损伤,严重影响其移植疗效和器官利用率。大量临床研究表明,常温区域机械灌注(NRP)技术的应用可显著提高DCDD供器官质量和移植成功率。目前,我国尚未制订NRP技术在DCDD中临床应用的专家共识,这影响了我国DCDD的规范化与高质量发展。为改变这一现状,本文总结国际研究进展,依据循证医学原则深入论证,形成《腹部常温区域机械灌注在以循环标准判定死亡的遗体器官捐献中的临床应用专家共识》。本共识重点介绍DCDD过程中应用NRP技术的执行规范及相应循证医学证据,旨在为NRP技术在DCDD供器官移植中应用的规范化、标准化提供参考和指导意见,推动我国NRP技术和DCDD供器官移植的快速发展。Organ transplantation is the most effective treatment for end-stage organ disease.One of the major challenges in organ transplantation is organ shortage.For this reason,more and more extended criteria donor organs including those from donation after circulatory determination of death(DCDD)are used in clinical practice.However,DCDD organs suffer from additional warm ischemic damage,which seriously affects transplant outcomes and organ utilization.Recent studies at home and abroad have shown that the application of normothermic regional perfusion(NRP)is able to improve the quality of organs and the success rate of transplantation.At present,an expert consensus on the clinical application of NRP in DCDD is lacking in China,which limits the standardization and high-quality development of DCDD in our country.We summarized the results of clinical studies and conducted in-depth discussions based on the principles of evidence-based medicine,to form this consensus on application of NRP in DCDD.This consensus focuses on the executive specification and corresponding research evidence of applying NRP technology in DCDD,aiming to provide reference opinions and guidance for the standardization of NRP in organ transplantation,and to promote the rapid development of NRP technology and DCDD organ transplantation in China.

关 键 词：以循环标准判定死亡的遗体器官捐献 常温区域机械灌注 器官移植 执行规范 

分 类 号：R47[医药卫生—护理学]