2022年济南市HIV感染者合并HCV感染情况分析  

Analysis on HIV-infected individuals co-infected with HCV in Jinan city in 2022

作　　者：李欣 黄玉洁 潘晶[1] 王庆昌 LI Xin;HUANG Yu-jie;PAN Jing;WANG Qing-chang(Institute for the Prevention of Viral Infectious Diseases,Jinan City Center for Disease Control and Prevention,Shandong 250021,China)

机构地区：[1]济南市疾病预防控制中心病毒所,山东250021

出　　处：《预防医学论坛》2024年第12期950-955,共6页Preventive Medicine Tribune

摘　　要：目的探讨济南市人类免疫缺陷病毒(HIV)感染者合并丙型肝炎病毒(HCV)感染的流行情况及两者的相关因素,为今后更好地开展HIV和HCV的防治工作提供参考依据。方法收集2022年度济南市既往确诊为HIV感染者的血清和信息资料,采用酶联免疫吸附法(ELISA)检测HCV抗体、采用RT-PCR法测定HCV RNA,采用t检验、方差分析、χ^(2)检验等统计学方法进行数据分析,分析HIV/HCV合并感染阳性率及其影响因素,并对基因分型进行检测。结果收集到HIV感染者723例,HCV抗体检测阳性率为5.1%(37/723)。单因素分析结果显示,HIV/HCV合并感染者与单纯HIV感染者在不同性别、民族、感染途径、病例来源和文化程度间的HCV抗体阳性率差异均有统计学意义(χ^(2)值分别为15.619、68.568、74.596、21.319、39.662,P均<0.001);HIV/HCV合并感染者的CD4^(+)在不同种族(t=2.331,P=0.027)和病例来源(F=5.017,P=0.012)方面的差异有统计学意义。在HCV抗体阳性感染者中进行HCV RNA检测阳性率为67.6%(25/37),以1b和3a基因亚型最常见。结论济南HIV感染者合并HCV感染比例较高,监狱监管场所注射毒品的人群是HIV/HCV合并感染率最高的人群,HIV/HCV合并感染者HCV基因型以1b和3a型为主。Objective To investigate the prevalence and associated factors of co-infection with human immunodeficiency virus(HIV)and hepatitis C virus(HCV)among HIV-infected individuals in Jinan city,so as to provide a reference for better prevention and control of HIV and HCV in the future.Methods Serum samples and information data were collected from individuals previously diagnosed with HIV infection in Jinan city in 2022.HCV antibodies were detected using the enzyme-linked immunosorbent assay(ELISA),and HCV RNA was measured by RT-PCR.Statistical methods such as t-tests,ANOVA,andχ^(2) tests were used for data analysis to study the positive rate of HIV/HCV co-infection and its influencing factors,with a brief analysis of genotyping.Results A total of 723HIV-infected individuals were enrolled,with an HCV antibody positive rate of 5.1%(37/723).Univariate analysis showed statistically significant differences in HCV antibody positive rates between HIV/HCV co-infected and HIV-only infected individuals across different genders,ethnicities,routes of infection,sources of cases,and educational levels(χ^(2) was 15.619,68.568,74.596,21.319,and 39.662,respectively,all P<0.001).The CD4^(+)counts of HIV/HCV co-infected individuals were statistically significantly different across different ethnicities(t=2.331,P=0.027)and sources of cases(F=5.017,P=0.012).Among HCV antibody-positive individuals,the positive rate of HCV RNA was 67.6%(25/37),with genotypes 1band 3abeing the most common in all subgroups.Conclusion The proportion of HIV-infected individuals co-infected with HCV is relatively high in Jinan city.The population injecting drugs in prison settings has the highest rate of HIV/HCV co-infection.The HCV genotypes of HIV/HCV co-infected individuals are predominantly 1band 3a.

关 键 词：人类免疫缺陷病毒 丙型肝炎病毒 HCV基因分型 

分 类 号：R512.91[医药卫生—内科学] R512.63[医药卫生—临床医学]