CO_(2)点阵激光联合胶原蛋白治疗妊娠纹的疗效观察  

Observation on Joint Efficacy of Fractional CO_(2)Laser and Collagen in Treatment of Striae Gravidarum

作　　者：张海荣[1] 王海佩 张伟[1] ZHANG Hairong;WANG Haipei;ZHANG Wei(Institute of Plastic Surgery Weifang Medical University,Weifang 261041,China)

机构地区：[1]潍坊医学院整形外科研究所,潍坊市261041

出　　处：《中国激光医学杂志》2024年第6期320-324,360,共6页Chinese Journal of Laser Medicine & Surgery

基　　金：潍坊市科技发展计划项目(2022YX039)。

摘　　要：目的探究CO_(2)点阵激光联合Ⅲ型胶原蛋白对腹部妊娠纹(striae gravidarum,SG)的有效性并观察其安全性。方法选择2020年1月至2024年1月,SG患者54例,随机分为实验组(A组)和对照组(B组),每组患者27例。两组均进行CO_(2)点阵激光治疗,先采用功率1 W,连续输出间断汽化瘢痕组织后,改用点阵模式治疗,光参数为能量120 mJ,间距0.6 mm,覆盖率13.5%,重复次数1,光斑形状方形,光斑扫描面积6 mm×6 mm,离散出光,均匀覆盖。激光治疗3次为一个疗程,每次治疗间隔2个月。B组患者在每次激光治疗后进行常规治疗,A组激光治疗后在常规治疗的基础上外敷Ⅲ型胶原蛋白治疗。末次激光治疗后2个月,观察两组患者恢复情况,比较临床疗效。同时比较两组患者的满意度和并发症发生情况。结果末次激光治疗后2个月,A组显著15例,有效7例,无效5例,总有效率为81%;B组显著10例,有效8例,无效9例,总有效率为67%,两组比较差异具有统计学意义(P<0.05)。A组患者满意度为81%,B组患者满意度为63%,两组比较差异无统计学意义(P>0.05)。A组瘙痒2例;B组瘙痒4例,瘢痕1例,未见其他并发症,两组比较差异具有统计学意义(P<0.05)。结论CO_(2)点阵激光联合Ⅲ型胶原蛋白治疗SG是一种有效的治疗方式,同时并发症的发生率低。Objective To investigate the joint efficacy of fractional CO_(2) laser and type Ⅲ collagen for the treatment of abdominal striae gravidarum(SG)and observe its complications.Methods Totally 54 SG patients treated between Jan.2020 and Jan.2024 were selected and randomly divided into an experimental group(Group A)and a control group(Group B),27 patients in each group.All the patients were given CO_(2) fractional laser treatment three times at an interval of 2 months,which was performed firstly in continuous mode at a power of 1 W to vaporize scar tissues and then in fractional mode(energy:120 mJ,spacing:0.6 mm,coverage:13.5%,repeat:1 time,spot shape:square,spot scanning area:6 mm×6 mm,discrete light emission and uniform coverage).While the patients in Group B being given only routine treatment after each laser treatment,the patients in Group A were applied type Ⅲ collagen in addition.Two months after the last laser treatment,the SG recovery of the patients was observed,and the clinical efficacy was compared between the two groups.Results After the treatment,the total effective rate was 81% in Group A(significantly effective patients:15,effective patients:7,ineffective patients:5)and 67% in Group B(significantly effective patients:10,effective patients:8,ineffective patients:9).The difference between the two groups was statistically significant(P<0.05).The satisfaction rate of patients was 81% in Group A and 6% in Group B respectively,and the difference was not remarkable(P>0.05).Despite of 2 cases of itching being found in Group A and 4 cases of itching and 1 case of scar being found in Group,no complication occurred in either group B.The difference between the two groups was statistically significant(P<0.05).Conclusions The combination of fractional CO_(2) laser and type Ⅲ collagen will treat stretch marks effectively while reducing the incidence of related complications.

关 键 词：激光 Ⅲ型胶原蛋白 妊娠纹 联合治疗 疗效 

分 类 号：R318.51[医药卫生—生物医学工程] R758.14[医药卫生—基础医学]