军事飞行员高尿酸血症患病情况及影响因素的Logistic回归分析  

Prevalence of hyperuricemia among military pilots and Logistic regression analysis of the influencing factors

作　　者：徐明 刘杨 王立栋 何娜 贾俊 王博强 宋新亮 Xu Ming;Liu Yang;Wang Lidong;He Na;Jia Jun;Wang Boqiang;Song Xinliang(Department of Health Management,Lintong Rehabilitation and Recuperation Center of PLA Joint Logistic Support Force,Xi′an 710600,China;The Seventh Department of Recuperation,Lintong Rehabilitation and Recuperation Center of PLA Joint Logistic Support Force,Xi′an 710600,China;The Third Department of Recuperation,Lintong Rehabilitation and Recuperation Center of PLA Joint Logistic Support Force,Xi′an 710600,China;The Eighth Department of Recuperation,Lintong Rehabilitation and Recuperation Center of PLA Joint Logistic Support Force,Xi′an 710600,China;The Sixth Department of Recuperation,Lintong Rehabilitation and Recuperation Center of PLA Joint Logistic Support Force,Xi′an 710600,China)

机构地区：[1]联勤保障部队临潼康复疗养中心健康管理部,西安710600 [2]联勤保障部队临潼康复疗养中心疗养七科,西安710600 [3]联勤保障部队临潼康复疗养中心疗养三科,西安710600 [4]联勤保障部队临潼康复疗养中心疗养八科,西安710600 [5]联勤保障部队临潼康复疗养中心疗养六科,西安710600

出　　处：《中华航空航天医学杂志》2024年第4期274-280,共7页Chinese Journal of Aerospace Medicine

摘　　要：目的探讨军事飞行员高尿酸血症(hyperuricemia,HUA)患病情况,分析其相关影响因素,为有效干预HUA提供依据。方法回顾性分析2021年1月至2023年10月部分参加健康体检的2700例军事飞行员的体检资料,按照是否患有HUA分为HUA组和非HUA组,比较2组飞行员年龄、身高、体质量、体质指数、飞行时间、血压、血尿酸、空腹血糖、总胆红素、白蛋白、血尿素氮、血肌酐、丙氨酸氨基转移酶、总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平,以及高血压、高脂血症、脂肪肝患病率差异。将飞行员按照年龄分为≤29、30~39、40~49和≥50岁4个组;按照飞行机种分为歼击机、轰炸机、运输机和直升机4个组。HUA、高血压、高脂血症及脂肪肝判定标准分别依据相关指南的标准判定。采用单因素二元Logistic回归分析飞行员HUA患病的影响因素,并将P<0.05的指标纳入多因素二元Logistic回归,进一步分析HUA患病的影响因素。结果HUA组821例(30.41%),非HUA组1879例(69.59%)。HUA组的体重(t=7.75,P<0.001)、体质指数(t=8.23,P<0.001)、收缩压(t=3.20,P=0.001)、舒张压(t=3.06,P=0.002)、血尿酸(t=62.83,P<0.001)、血尿素氮(t=3.41,P=0.001)、血肌酐(t=8.88,P<0.001)、丙氨酸氨基转移酶(t=5.56,P<0.001)、总胆固醇(t=3.27,P=0.001)、甘油三酯(Z=9.54,P<0.001)水平,以及高血压(χ^(2)=7.48,P=0.006)、高脂血症(χ^(2)=42.74,P<0.001)、脂肪肝(χ^(2)=22.51,P<0.001)患病率均高于非HUA组,而高密度脂蛋白胆固醇水平低于非HUA组,差异有统计学意义(t=5.91,P<0.001)。不同年龄、机种飞行员HUA患病率差异无统计学意义(P均>0.05)。超重(OR=1.392,95%CI:1.159~1.672)、肥胖(OR=1.891,95%CI:1.197~2.987)、甘油三酯(OR=1.246,95%CI:1.128~1.377)、血尿素氮(OR=1.079,95%CI:1.000~1.163)以及血肌酐(OR=1.036,95%CI:1.028~1.044)升高是HUA的危险因素;高密度脂蛋白胆固醇(OR=0.567,95%CI:0.389~0.825)升高是HUA患病的Objective To provide references for effective intervention of hyperuricemia(HUA)by investigating the prevalence of HUA in military pilots and analyzing its relevant influencing factors.Methods The physical examination data of 2700 military pilots who received physical examinations from January 2021 to October 2023 were retrospectively analyzed.The above pilots were divided into HUA group and non-HUA group according to whether they had HUA.The differences in age,height,weight,body mass index,flying hours,blood pressure,blood uric acid,fasting blood glucose,total bilirubin,albumin,blood urea nitrogen,blood creatinine,alanine aminotransferase,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol levels,as well as the prevalence of hypertension,hyperlipidemia,and fatty liver were compared between 2 groups.The pilots were grouped by age(≤29 years,30-39 years,40-49 years,≥50 years)and by the aircraft types(fighter,bombers,transporter,helicopter).The criteria for determining HUA,hypertension,hyperlipidemia,and fatty liver were based on the relevant guidelines.The influencing factors for the prevalence of HUA were analyzed through binary Logistic regression.Single factor binary Logistic regression was used to analyze the influencing factors of the prevalence of HUA in pilots,and P<0.05 index was included in multi-factor binary Logistic regression to further analyze the influencing factors of the occurrence of HUA.Results There were 821 cases(30.41%)in HUA group and 1879 cases(69.59%)in non-HUA group.The weight(t=7.75,P<0.001),body mass index(t=8.23,P<0.001),systolic blood pressure(t=3.20,P=0.001),diastolic blood pressure(t=3.06,P=0.002),serum uric acid(t=62.83,P<0.001),blood urea nitrogen(t=3.41,P=0.001),serum creatinine(t=8.88,P<0.001),alanine aminotransferase(t=5.56,P<0.001),total cholesterol(t=3.27,P=0.001),triglyceride(Z=9.54,P<0.001),as well as the prevalence of hypertension(χ^(2)=7.48,P=0.006),hyperlipidemia(χ^(2)=42.74,P<0.001),and fatty liver(χ^(2)=22.51,P

关 键 词：高尿酸血症 患病率 影响因素分析 军事飞行员 

分 类 号：R856.5[医药卫生—航空、航天与航海医学]