清肺化痰方联合虎符铜砭刮痧治疗痰热壅肺型慢性阻塞性肺疾病急性加重期的临床疗效  

Clinical Efficacy of Qingfei Huatan Formula Combined with Hufu Tongbian Scrapping in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm Heat Obstructing Lung Type

作　　者：谷思薇 唐鸿[2] 林翠萍 方小谦 GU Siwei;TANG Hong;LIN Cuiping;FANG Xiaoqian(Department of TCM Specialty Clinic,Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210018,China;Department of Pulmonary Diseases,Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210018,China;Department of Nursing,Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine,Nanjing 210018,China)

机构地区：[1]南京中医药大学附属南京市中西医结合医院中医特色门诊,江苏省南京市210018 [2]南京中医药大学附属南京市中西医结合医院肺病科,江苏省南京市210018 [3]南京中医药大学附属南京市中西医结合医院护理部,江苏省南京市210018

出　　处：《实用心脑肺血管病杂志》2025年第5期16-20,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：江苏省中医经典名方评价与转化工程研究中心开放课题立项资助项目(GCZX-20240104)。

摘　　要：目的探讨清肺化痰方联合虎符铜砭刮痧治疗痰热壅肺型慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法选取2023年1月—2024年3月南京中医药大学附属南京市中西医结合医院收治的痰热壅肺型AECOPD患者130例作为研究对象,采用随机数字表法将患者分为中药组43例、刮痧组43例、联合组44例。中药组患者采用清肺化痰方治疗,刮痧组患者采用虎符铜砭刮痧治疗,联合组患者采用清肺化痰方联合虎符铜砭刮痧治疗。三组均连续治疗7 d。比较三组临床疗效,治疗前、治疗7 d后炎症因子(血清TNF-α、IL-8、CRP水平)、T淋巴细胞亚群(CD4^(+)T淋巴细胞百分比、CD8+T淋巴细胞百分比、CD4^(+)T淋巴细胞/CD8+T淋巴细胞)、肺功能指标〔呼气流量峰值(PEF)、FEV1/FVC〕、BODE指数,并观察患者治疗期间不良反应发生情况。结果联合组总有效率高于中药组、刮痧组(P<0.05)。治疗7 d后,联合组血清TNF-α、IL-8、CRP水平低于中药组、刮痧组(P<0.05)。治疗7 d后,联合组CD4^(+)T淋巴细胞百分比、CD4^(+)T淋巴细胞/CD8+T淋巴细胞高于中药组、刮痧组,CD8+T淋巴细胞百分比低于中药组、刮痧组(P<0.05)。治疗7 d后,联合组PEF、FEV1/FVC高于中药组、刮痧组,BODE指数低于中药组、刮痧组(P<0.05)。三组治疗期间均未发生不良反应。结论清肺化痰方联合虎符铜砭刮痧治疗痰热壅肺型AECOPD的疗效确切,可有效减轻炎症反应,改善肺功能,提高机体免疫功能,且安全性较高。Objective To investigate the clinical efficacy of Qingfei Huatan formula combined with Hufu Tongbian scrapping in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with phlegm heat obstructing lung type.Methods A total of 130 AECOPD with phlegm heat obstructing lung type patients admitted to Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine from January 2023 to March 2024 were selected as study objects.Patients were divided into the TCM group with 43 cases,scrapping group with 43 cases and the combination group with 44 cases according to random number table method.Patients in the TCM group were treated with Qingfei Huatan formula,patients in the scrapping group were treated with Hufu Tongbian scrapping,and patients in the combination group were treated with Qingfei Huatan formula combined with Hufu Tongbian scrapping.All groups were treated for+7 days.Clinical efficacy,inflammatory factors(serum TNF-α,IL-8,CRP levels),T lymphocyte subsets(percentage of CD4 T+++lymphocytes,percentage of CD8 T lymphocytes,CD4 T lymphocytes/CD8 T lymphocytes),pulmonary function indicators[peak expiratory flow(PEF),FEV1/FVC],and BODE index before treatment and after 7 days of treatment were compared among the three groups.Incidence of adverse reactions of the two groups were observed.Results The total effective rate of the combination group was higher than that in the TCM group and scrapping group(P<0.05).After 7 days of treatment,serum levels of TNF-α,IL-8,CRP in the combination group were lower than those in the TCM group and scrapping group(P<0.05).After 7 days of+++treatment,percentage of CD4 T lymphocytes,CD4 T lymphocytes/CD8 T lymphocytes in the combination group were higher+than those in the TCM group and scrapping group,percentage of CD8 T lymphocytes was lower than that in the TCM group and scrapping group(P<0.05).After 7 days of treatment,PEF,FEV1/FVC in the combination group were higher than those in the TCM group a

关 键 词：肺疾病 慢性阻塞性 急性加重期 痰热壅肺 清肺化痰方 虎符铜砭刮痧 

分 类 号：R563.9[医药卫生—呼吸系统]