预防性服用阿司匹林与慢性阻塞性肺疾病的关系:基于NHANES横断面研究  

Relationship between Prophylactic Use of Aspirin and Chronic Obstructive Pulmonary Disease:a Cross-Sectional Study Based on NHANES

作　　者：卢嘉贤 陈冬梅[1] LU Jiaxian;CHEN Dongmei(Pharmaceutical Department,Xiaolan People's Hospital of Zhongshan/the Fifth People's Hospital of Zhongshan,Zhongshan 528415,China)

机构地区：[1]广东省中山市小榄人民医院,中山市第五人民医院药学部,528415

出　　处：《实用心脑肺血管病杂志》2025年第5期21-25,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：中山市医学科研项目(2024A020248)。

摘　　要：目的探讨预防性服用阿司匹林与慢性阻塞性肺疾病(COPD)的关系。方法本研究数据为美国国家健康与营养检查调查(NHANES)2017—2020年调查周期数据,纳入所有成年参与者,按照是否罹患COPD将其分为对照组和COPD组。记录参与者是否预防性服用阿司匹林及其剂量;收集影响预防性服用阿司匹林与COPD关系的协变量,包括性别、年龄、种族、出生地、受教育程度、婚姻状况、收入与贫困线比值、BMI、合并糖尿病情况、合并高血压情况、饮酒情况、吸烟情况。采用倾向性匹配加权法(PSW)校正对照组和COPD组的协变量,采用标准化均数差(SMD)评估两组临床资料的均衡性,采用非条件Logistic回归分析和加权Logistic回归分析探讨预防性服用阿司匹林与COPD的关系,绘制限制性立方样条(RCS)曲线以分析预防性服用阿司匹林剂量与COPD的剂量-反应关系。结果最终纳入2910例参与者作为研究对象,其中COPD 380例(COPD组),COPD患病率为13.06%;非COPD 2530例(对照组)。PSW处理后,两组性别、年龄、种族、出生地、受教育程度、婚姻状况、收入与贫困线比值、BMI及合并糖尿病、合并高血压、饮酒、吸烟者占比比较,差异均无统计学意义(P>0.05),两组临床资料分布均衡(SMD<0.10)。非条件Logistic回归分析结果显示,在校正所有协变量后,预防性服用阿司匹林与COPD患病风险升高相关[OR=1.303,95%CI(1.019~1.668)]。加权Logistic回归分析结果显示,在校正所有协变量后,预防性服用阿司匹林与COPD患病风险升高相关[OR=1.836,95%CI(1.339~2.517)]。RCS曲线分析结果显示,预防性服用阿司匹林剂量与COPD发生风险呈典型的正向线性关系(P总体=0.014,P非线性=0.675)。结论预防性服用阿司匹林与COPD患病风险升高相关,其剂量与COPD发生风险呈正向线性关系。Objective To investigate the relationship between prophylactic use of aspirin and chronic obstructive pulmonary disease(COPD).Methods The data of this study were from the 2017—2020 survey cycle of the National Health and Nutrition Examination Survey(NHANES).All adult participants were included and divided into control group and COPD group according to whether they had COPD.Whether prophylactic use of aspirin and its dosage were recorded.The covariates of the relationship between prophylactic use of aspirin and COPD were collected,including gender,age,race,place of birth,education level,marital status,ratio of income to poverty line,BMI,diabetes,hypertension,drinking and smoking.The propensity matching weighted(PSW)was used to correct the covariates of the control group and the COPD group.Standardized mean difference(SMD)was used to evaluate the balance of clinical data between the two groups.Non-conditional Logistic regression analysis and weighted Logistic regression analysis were used to explore the relationship between prophylactic use of aspirin and COPD.The restrictive cubic spline(RCS)curve was drawn to analyze the dose-response relationship between prophylactic use dosage of aspirin and COPD.Results Finally,2910 participants were included in the study,including 380 cases of COPD(COPD group),and the prevalence of COPD was 13.06%.There were 2530 cases of non-COPD(control group).After PSW,there were no significant differences in gender,age,race,place of birth,education level,marital status,ratio of income to poverty line,BMI and the proportion of patients with diabetes,hypertension,drinking and smoking between the two groups(P>0.05).The clinical data of the two groups was balanced(SMD<0.10).The results of non-conditional Logistic regression analysis showed that,after adjusting for all covariates,prophylactic use of aspirin was associated with an increased risk of COPD[OR=1.303,95%CI(1.019-1.668)].Weighted Logistic regression analysis showed that,after adjusting for all covariates,prophylactic use of aspirin

关 键 词：肺疾病 慢性阻塞性 阿司匹林 倾向匹配加权 NHANES 横断面研究 

分 类 号：R563.9[医药卫生—呼吸系统]