肺炎克雷伯菌耐药机制、耐药基因及毒力因子的研究进展  

Research Progress of Resistance Mechanisms,Resistance Genes and Virulence Factors of Klebsiella Pneumoniae

作　　者：颜琪 张萍淑 李雯 欧亚 龙清熙 吴琪 元小冬 YAN Qi;ZHANG Pingshu;LI Wen;OU Ya;LONG Qingxi;WU Qi;YUAN Xiaodong(Department of Neurology,Kailuan General Hospital Affiliated to North China University of Science and Technology,Tangshan 063000,China;Hebei Provincial Key Laboratory of Neurobiological Function,Tangshan 063000,China)

机构地区：[1]华北理工大学附属开滦总医院神经内科,河北省唐山市063000 [2]神经生物机能重点实验室,河北省唐山市063000

出　　处：《实用心脑肺血管病杂志》2025年第5期133-140,共8页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：2023年河北省医学适用技术跟踪项目(GZ2023049);2021年度河北省医学科学研究课题计划项目(20210526);2020年度河北省创新能力提升计划项目(20567622H)。

摘　　要：肺炎克雷伯菌(KP)是一种重要的多重耐药(MDR)病原菌,其可引起住院患者发生一系列感染。近年来随着抗生素广泛使用,KP医院感染率逐年攀升,甚至出现了同时具有MDR和高毒力性的碳青霉烯类耐药高毒力肺炎克雷伯菌(CR-hvKP),这给临床医生选择有效抗生素带来了严峻挑战。此外,KP的耐药机制复杂多样,并携带多种毒力因子。基于此,本文综述了KP的耐药机制、耐药基因及毒力因子的研究进展,以期更好地了解KP并制定高效可行的防治策略。Klebsiella pneumoniae(KP)is an important multidrug-resistant(MDR)pathogen,which can cause a series of infections in hospitalized patients.With the widespread use of antibiotics in recent years,the rate of KP hospital infections has been increasing year by year,and even the emergence of carbapenem-resistant highly virulent Klebsiella pneumoniae(CR-hvKP)with both MDR and high virulence has posed a serious challenge to clinicians in selecting effective antibiotics.In addition,KP has complex and diverse resistance mechanisms and carries multiple virulence factors.Based on this,this article reviews the research progress of resistance mechanisms,resistance genes and virulence factors of KP,in order to better understand KP and develop efficient and feasible prevention and treatment strategies.

关 键 词：肺炎克雷伯菌 抗药性 细菌 抗菌药 耐药基因 毒力因子 综述 

分 类 号：R378.99[医药卫生—病原生物学]