血清IL-17、eotaxin-3联合对慢性阻塞性肺疾病急性加重期患者预后不良的预测价值  

Predictive value of serum IL-17 combined with eotaxin-3 for poor prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：王娜 翟莉 张琳 吕俊刚 曹甜甜 单青 刘辉[2] WANG Na;ZHAI Li;ZHANG Lin;LYU Jungang;CAO Tiantian;DAN Qing;LIU Hui(Three Departments of Internal Medicine,Beijing Municipal Armed Police Force Hospital,Beijing 100027,China;Department of Weigongqiao Outpatient,Jingxi Medical District,General Hospital of the People′s Liberation Army,Beijing 100000,China)

机构地区：[1]武警北京市总队医院内三科,北京100027 [2]解放军总医院京西医疗区魏公桥门诊部,北京100000

出　　处：《国际检验医学杂志》2025年第6期752-756,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨血清白细胞介素-17(IL-17)、嗜酸性粒细胞趋化因子-3(eotaxin-3)联合对慢性阻塞性肺疾病急性加重期(AECOPD)患者预后不良的预测价值。方法选取2018年5月至2023年7月武警北京市总队医院收治的213例AECOPD患者为疾病组,根据患者预后情况分为预后良好组(133例)和预后不良组(80例)。另同期选取武警北京市总队医院的205例体检健康者为健康组。采用酶联免疫吸附试验检测血清IL-17、eotaxin-3水平,比较预后不良组和预后良好组临床资料。采用Pearson相关分析AECOPD患者血清中IL-17水平与eotaxin-3的相关性,多因素Logistic回归分析影响AECOPD患者预后的相关因素,受试者工作特征(ROC)曲线评估血清IL-17、eotaxin-3水平对AECOPD患者预后的预测价值。结果与健康组比较,疾病组血清IL-17、eotaxin-3水平升高(P<0.05)。与预后良好组比较,预后不良组血清IL-17、eotaxin-3水平升高(P<0.05)。AECOPD患者血清IL-17水平与eotaxin-3呈正相关(r=0.537,P<0.001)。预后不良组和预后良好组慢性阻塞性肺疾病全球倡议(GOLD)分级、血氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))比较,差异有统计学意义(P<0.05),且GOLD分级、PaCO_(2)、血清IL-17及eotaxin-3水平是AECOPD患者预后不良的危险因素(P<0.05),PaO_(2)是AECOPD患者预后不良的保护因素(P<0.05)。血清IL-17、eotaxin-3联合预测AECOPD患者预后的曲线下面积为0.885,灵敏度为80.00%,特异度为83.46%,优于IL-17、eotaxin-3单独预测(Z_(二者联合-IL-17)=4.045,P=0.001、Z_(二者联合-eotaxin-3)=3.254,P=0.001)。结论AECOPD患者血清IL-17、eotaxin-3水平均升高,二者联合对AECOPD患者的预后情况具有预测价值。Objective To investigate the predictive value of serum interleukin-17(IL-17)combined with eotaxin-3 for poor prognosis in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 213 patients with AECOPD admitted to Beijing Municipal Armed Police Force Hospital from May 2018 to July 2023 were selected as the disease group.According to the prognosis of patients,they were divided into good prognosis group(133 cases)and poor prognosis group(80 cases).At the same time,205 physical examination healthy people in Beijing Municipal Armed Police Force Hospital were selected as the healthy group.The serum levels of IL-17 and eotaxin-3 were detected by enzyme-linked immunosorbent assay.The clinical data of poor prognosis group and good prognosis group were compared.Pearson correlation analysis was used to analyze the correlation between serum IL-17 level and eotaxin-3 in AECOPD patients.Multivariate Logistic regression analysis was used to analyze the related factors affecting the prognosis of AECOPD patients.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of serum IL-17 and eotaxin-3 levels for the prognosis of AECOPD patients.Results Compared with the healthy group,the serum levels of IL-17 and eotaxin-3 were increased in the disease group(P<0.05).Compared with the good prognosis group,the poor prognosis group had significant increases in serum IL-17 and eotaxin-3 levels(P<0.05).Serum IL-17 level was positively correlated with eotaxin-3 in AECOPD patients(r=0.537,P<0.001).There were significant differences in Global Initiative for Chronic Obstructive Lung Disease(GOLD)grade,blood oxygen partial pressure(PaO_(2))and carbon dioxide partial pressure(PaCO_(2))between the poor prognosis group and the good prognosis group(P<0.05).GOLD grade,PaCO_(2),serum IL-17 and eotaxin-3 levels were risk factors for poor prognosis in patients with AECOPD(P<0.05),and PaO_(2)was a protective factor for poor prognosis in patients with AECOPD(P<0.05).The area

关 键 词：白细胞介素-17 嗜酸性粒细胞趋化因子-3 慢性阻塞性肺疾病急性加重期 预后 

分 类 号：R563[医药卫生—呼吸系统]