Perinatal risk factors and preliminary prediction of conductive hearing loss in infancy  

作　　者：Jiao Zhang Minghui Zhao Wei Shi Haina Ding Lan Lan Yun Gao Dayong Wang Qiuju Wang 

机构地区：[1]Department of Audiology and Vestibular Medicine,Senior Department of Otolaryngology,Head and Neck Surgery,the sixth Medical Center of Chinese PLA General Hospital,Beijing,100853,China [2]National Clinical Research Center for Otolaryngologic Diseases,Beijing,100853,China [3]The Third Affiliated Hospital of Zhejiang Chinese Medical University,Haangzhou,310005,Zhejiang,China

出　　处：《Journal of Otology》2025年第1期33-38,共6页中华耳科学杂志(英文版)

基　　金：supported by the grants of the National Key Research and Development Program of China(Grant No.2023YFC2508400);the National Natural Science Foundation of China(Grant No.82350005).

摘　　要：Purpose To investigate the perinatal risk factors for conductive hearing loss(CHL)in infancy and develop an initial prediction model to facilitate accurate diagnosis and early detection of CHL.Method This retrospective study utilized data from the Newborn Cohort Study of Hearing Loss(ChiCTR2100049765).Infants who underwent diagnostic audiological assessments at our hospital between January 2003 and June 2024 were included.Data analysis was conducted using R(version 4.4.1)to construct an initial prediction model for CHL in infancy,applying the LASSO regression technique.Results A total of 661 infants(1322 ears)were included,with 1253 ears in the normal hearing group and 69 ears in the CHL group.Statistically significant differences were observed between the groups in the following factors:parent-reported infant response to sound,craniofacial deformities,neonatal hemolysis,jaundice treatment,and neonatal hypoglycemia.A multivariate prediction model and nomogram for CHL in infancy were developed and validated,achieving an accuracy of 92.5%and a specificity of 91.3%.Conclusions This study identified key risk factors for CHL in infancy and developed a preliminary predictive model,improving the diagnostic accuracy for CHL.Improved diagnostic precision can decrease misdiagnoses,reduce delays in treatment,and limit unnecessary antimicrobial prescriptions for infants.

关 键 词：conductive hearing loss INFANT PERINATAL risk factors PREDICTION 

分 类 号：R764[医药卫生—耳鼻咽喉科] R722[医药卫生—临床医学]