Microneedles for non-transdermal drug delivery:design strategies and current applications  

非透皮给药微针:设计策略及应用现状

作　　者：Jinhong Xu Xiangyi Liao Danli Chen Xiuzhuo Jia Xufeng Niu 许锦红;廖相宜;陈丹藜;贾秀镯;牛旭锋(保定市第四中心医院药剂科,保定市072350;北京航空航天大学生物与医学工程学院生物力学与力学生物学教育部重点实验室,北京市生物医学工程高精尖创新中心,北京市100083;保定市第四中心医院医疗事业科,保定市072350)

机构地区：[1]Department of Pharmacy,The Fourth Central Hospital of Baoding City,Baoding 072350,China [2]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100083,China [3]Department of Medical Business,The Fourth Central Hospital of Baoding City,Baoding 072350,China

出　　处：《Bio-Design and Manufacturing》2025年第2期243-274,I0003,共33页生物设计与制造(英文)

基　　金：financial support from the Beijing Natural Science Foundation(No.L234020);the National Natural Science Foundation of China(Nos.12472325 and 12272032);the 111 Project(No.B13003).

摘　　要：Microneedles(MNs)are an innovative and viable option for drug delivery that offer the distinct advantages of minimal invasiveness,painlessness,stable drug loading,efficient drug permeation,and biocompatibility.MNs were first used to penetrate the skin surface and facilitate transcutaneous drug delivery with great success.Recent applications of MNs have extended to non-transdermal drug delivery,specifically,to various tissues and organs.This review captures the fabrication methods for MNs,discusses advanced design strategies for achieving controlled drug release,and summarizes current MN applications in delivering multiple therapeutic agents to the cardiovascular,digestive(e.g.,oral cavity),reproductive,and central nervous systems.The findings in this review would contribute toward the improved designs of MN systems that can be modified according to purpose,including material selection,structural design,choice of fabrication methods,and tissue considerations,to determine the optimal therapeutic regimen for the target treatment area.微针是一种创新和可行的药物递送选择,具有微创、无痛、稳定的药物负荷,有效的药物渗透与生物相容性等独特优势。微针已被首先用于皮肤表面穿刺后促进透皮给药,并取得了巨大成功。而微针的最新应用已经扩展到非透皮给药领域,包括各类组织与器官。本文综述了微针的制备方法,讨论了实现药物控制释放的先进设计策略,并总结了目前微针在向心血管、消化(如口腔)、生殖和中枢神经系统递送多种治疗药物方面的应用。本综述将有助于改进微针体系的设计,以便根据治疗目的,对包括材料选择、结构设计、制备方法选择以及组织考虑因素在内的各方面进行调整,以确定目标区域的最佳治疗方案。

关 键 词：Microneedles(MNs) Biocompatible materials Non-transdermal drug delivery Controlled release 

分 类 号：TG1[金属学及工艺—金属学]