孕期补充益生菌对妊娠期并发症影响研究进展  

Research update on the effects of probiotic supplementation during pregnancy on pregnancy complications: a systematic literature review

作　　者：杨晶[1,2] 王小川 刘博蕊 张小燕 高晓宇[1,2] 胡嘉晋 YANG Jing;WANG Xiaochuan;LIU Borui;ZHANG Xiaoyan;GAO Xiaoyu;HU Jiajin(Key Laboratory of Obesity and Glucose,Lipid Associated Metabolic Diseases of Liaoning Province/Health Sciences Institute,China Medical University,Shenyang 110122,China;Chinese Medical University Birth Cohort Study,CMUBC,Shenyang 110004,China)

机构地区：[1]辽宁省肥胖与糖脂代谢性疾病重点实验室/中国医科大学健康科学研究院,沈阳110122 [2]中国医科大学出生队列研究中心,沈阳110004

出　　处：《中国公共卫生》2024年第12期1515-1519,共5页Chinese Journal of Public Health

基　　金：国家自然科学基金(82103860)。

摘　　要：近年来,越来越多研究证据表明孕期补充益生菌与妊娠期并发症的防治之间存在关联。益生菌作为肠道微生态调节剂,因具有抗炎和免疫调节等生理功能,可能在预防妊娠期并发症、改善临床症状方面具有潜在作用。然而,受限于现阶段益生菌临床研究的缺乏和相关研究结论的异质性,孕期补充益生菌对妊娠期并发症的影响仍需要进一步归纳总结。本文就孕期补充益生菌对防治妊娠期糖尿病、子痫前期、妊娠期肝内胆汁淤积症、早产、自然流产等常见妊娠期并发症的潜在效果进行综述,以期为益生菌补充剂在妊娠期并发症中的临床防治提供参考依据。A growing body of research suggests a correlation between probiotic supplementation during pregnancy and the prevention and treatment of pregnancy complications.As modulators of gut microbiota,probiotics possess anti-inflammatory and immunomodulatory properties,potentially offering benefits in preventing pregnancy complications and improving clinical symptoms.This review aims to summarize the potential effects of probiotic supplementation during pregnancy on common pregnancy complications,including gestational diabetes mellitus,preeclampsia,intrahepatic cholestasis of pregnancy,premature birth and spontaneous abortion,due to the current limitations in clinical research on probiotics and the heterogeneity of existing findings.This review provides a reference for the clinical application of probiotic supplements in the prevention and treatment of pregnancy complications.

关 键 词：妊娠 益生菌补充剂 妊娠期并发症 预防 治疗 

分 类 号：R714.25[医药卫生—妇产科学]