Approaching onchocerciasis elimination in Equatorial Guinea:Near zero transmission and public health implication  

作　　者：Policarpo Ncogo Ana Hernández‑González Thuy‑Huong Ta‑Tang Lidia Redondo AnaÁlvarez Maria J.Perteguer JoséM.Rubio Rufno Nguema Justino Nguema Marta García Laura Reguero Teresa Valverde Marta Lanza Laura Cerrada‑Gálvez Maria Rebollo Jorge Cano Agustín Benito Zaida Herrador 

机构地区：[1]National Onchocerciasis and Other Filariasis Control Programme.Ministry of Health,Malabo,Equatorial Guinea [2]National Centre for Tropical Medi‑cine,Institute of Health Carlos III(ISCIII in Spanish),Madrid,Spain [3]Min‑istry of Health,Fundación Estatal,Infancia y Bienestar Social,F.S.P.(CSAI),Madrid,Spain [4]National Centre of Microbiology,Institute of Health Carlos III,Madrid,Spain [5]CIBERINFEC.Institute of Health Carlos III,Madrid,Spain [6]Global Program for Onchocerciasis Elimination&Scabies Control,Depart‑ment of Control of Neglected Tropical Diseases,World Health Organization,Geneva,Switzerland [7]Expanded Special Project for Elimination of NTDs,World Health Organization Regional Ofce for Africa,Brazzaville,Republic of Congo [8]National Centre of Epidemiology,Health Institute Carlos III,Madrid,Spain [9]CIBERESP,Institute of Health Carlos III,Madrid,Spain

出　　处：《Infectious Diseases of Poverty》2024年第6期102-103,共2页贫困所致传染病(英文)

基　　金：Funding WHO(GNQ/AFRO/19–194);Task Force for Global Health(NTDSC#093‑2016);Instituto de Salud Carlos III(AESI‑PI17CIII/00019&AESI‑PI20CIII/00034)and CIBERINFEC‑UE‑(CB21/13/00120).

摘　　要：Background Onchocerciasis and lymphatic filariasis(LF)are endemic in Equatorial Guinea with notable variations in disease incidence between island and mainland regions.Historically,efforts to control and map these diseases were concentrated in Bioko Island,where loiasis is absent,allowing for targeted onchocerciasis interruption strategies.With the cessation of onchocerciasis transmission on Bioko and no reported cases on Annobon island,assessing the trans-mission status in the previously unaddressed mainland region has become imperative.Mapping efforts in mainland Equatorial Guinea have proven low to moderate level of transmission for LF and onchocerciasis,although the results so far have not been very conclusive.The current study aims to update the prevalence estimates for onchocerciasis and LF in mainland Equatorial Guinea using various diagnostic techniques.Methods This is the first cross-sectional study carried out to estimate the prevalence of onchocerciasis and LF in the mainland area of Equatorial Guinea,from September to December 2019,based on the combination of skin snip biopsies,thick blood smears,laboratory serological tests(ELISA tests for the detection of lgG4 antibodies against Onchocerca volvulus recombinant antigen Ov16 and Wuchereria bancrofti recombinant antigen Wb123)and molecular laboratory tests.Frequencies and prevalence rates,along with 95%confidence intervals for interval estimation of a binomial proportion,were computed.Results The overall onchocerciasis seroprevalence calculated for the study was 0.3%(95%CI:0.1 to 0.5%).Micro-scopic examination of skin biopsies from the eight individuals seropositive for Ov16,out of the 3951 individuals initially tested,revealed no O.volvulus microfilariae.However,DNA extracted from one skin snip was successfully amplified,with subsequent sequencing confirming the presence of O.volvulus.Among the 3951 individuals,182 were found to have anti-Wb123 antibodies,suggesting exposure to W.bancrofti,with an estimated seroprevalence of 4.6%(95%CI:4.0 to 5.3%).Mi

关 键 词：ONCHOCERCIASIS Lymphatic flariasis Mapping PCR SEROLOGY Equatorial Guinea 

分 类 号：P73[天文地球—海洋科学]