Global burden of viral infectious diseases of poverty based on Global Burden of Diseases Study 2021  

作　　者：Xin-Chen Li Yan-Yan Zhang Qi-Yu Zhang Jing-Shu Liu Jin-Jun Ran Le-Fei Han Xiao-Xi Zhang 

机构地区：[1]School of Global Health,Chinese Center for Tropical Diseases Research,Shanghai Jiao Tong University School of Medicine,Shanghai,People’s Republic of China [2]Institute of One Health,Shanghai Jiao Tong University,Shanghai,People’s Republic of China [3]School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai,People’s Republic of China

出　　处：《Infectious Diseases of Poverty》2024年第5期53-67,共15页贫困所致传染病(英文)

基　　金：National Natural Science Foundation of China(No.72204160);International Joint Laboratory on Tropical Diseases Control in Greater Mekong Subregion(No.21410750200);Open Research Project of the Key Laboratory of Parasite Pathogen and Vector Biology of National Health Commission of the People’s Republic of China(No.NHCKFKT2022-16)。

摘　　要：Background Viral infectious diseases of poverty(vIDPs)remain a significant global health challenge.Despite their profound impact,the burden of these diseases is not comprehensively quantified.This study aims to analyze the global burden of six major vIDPs,including coronavirus disease 2019(COVID-19),HIV/AIDS,acute hepatitis,dengue,rabies,and Ebola virus disease(EVD),using data from the Global Burden of Diseases,Injuries,and Risk Factors Study 2021(GBD 2021).Methods Following the GBD 2021 framework,we analyzed the incidence,mortality,and disability-adjusted life years(DALYs)of the six vIDPs across 204 countries and territories from 1990 to 2021.We examined the association between the Socio-Demographic Index(SDI)and the burden of vIDPs.All estimates were reported as numbers and rates per 100,000 population,calculated using the Bayesian statistical model employed by GBD 2021,with 95%uncertainty intervals(UI).Results In 2021,vIDPs caused approximately 8.7 million deaths and 259.2 million DALYs,accounting for 12.8%and 9.0%of the global all-cause totals,respectively.Globally,the burden of vIDPs varied significantly:COVID-19 caused around 7.9 million(95%UI:7.5,8.4)deaths and 212.0 million(95%UI 197.9,234.7)DALYs in 2021.Acute hepatitis had the second-highest age-standardized incidence rate,with 3411.5(95%UI:3201.8,3631.3)per 100,000 population,while HIV/AIDS had a high age-standardized prevalence rate,with 483.1(95%UI:459.0,511.4)per 100,000 population.Dengue incidence cases rose from 26.5 million(95%UI:3.9,51.9)in 1990 to 59.0 million(95%UI:15.5,106.9)in 2021.Rabies,although reduced in prevalence,continued to pose a significant mortality risk.EVD had the lowest overall burden but significant outbreak impacts.Age-standardized DALY rates for vIDPs were significantly negatively correlated with SDI:acute hepatitis(r=-0.8,P<0.0001),rabies(r=-0.7,P<0.0001),HIV/AIDS(r=-0.6,P<0.0001),COVID-19(r=-0.5,P<0.0001),dengue(r=-0.4,P<0.0001),and EVD(r=-0.2,P<0.005).Conclusions VIDPs pose major public health challenges worldwide,with si

关 键 词：Viral infectious diseases of poverty Global Burden of Disease 2021 Disability-adjusted life years Socio-Demographic Index 

分 类 号：R51[医药卫生—内科学]