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作 者:Zepeng Zhao Qin Li Feng Ye Haoliang Wang Jianfeng Wang Hui Yu Xiangyang Li Chao Yang
机构地区:[1]School of Chemical Engineering,Sichuan University,Chengdu 610065,China [2]CAS Key Laboratory of Green Process and Engineering,State Key Laboratory of Petroleum Molecular&Process Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China [3]School of Ecology and Environment,Zhengzhou University,Zhengzhou 450001,China
出 处:《Chinese Journal of Chemical Engineering》2025年第1期293-300,共8页中国化学工程学报(英文版)
基 金:National Natural Science Foundation of China(22178228,22178326)
摘 要:A cylindrical chamber with a rotating bottom holds significant potential for application in cell culture bioreactors due to its ability to generate more stable swirling flows.In order to control vortex breakdown within the chamber,this study first establishes a computational fluid dynamics simulation coupled with the level set method.Verified by experimental results in literature,this method accurately simulates the position and shape of vortex breakdown,and also predicts the critical Reynolds numbers for the appearance and detachment of vortex breakdown bubbles from the center.Additionally,it precisely captures the gas-liquid interface and depicts the vortex breakdown phenomenon in the air above the liquid for the first time.Finally,it predicts the impact of physical property of gas-liquid systems on vortex breakdown in response to significant changes in viscosity of microbial process systems.
关 键 词:Vortex breakdown Level set Microbial cultivation Micro-bioreactor
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