轻中度颅脑损伤患者血清降钙素原、C反应蛋白水平变化及其预测认知功能障碍的价值分析  

Changes in Serum Procalcitonin and C-Reactive Protein Levels in Patients with Mild to Moderate Traumatic Brain Injury and Their Predictive Value for Cognitive Dysfunction

作　　者：郑洛翰[1] 林鸿[1] 郑佳坤 Zheng Luohan;Lin Hong;Zheng Jiakun(Department of Neurosurgery,Chaozhou Central Hospital,Chaozhou 521000,Guangdong Province,China;General Department,Chaoan Kanghua Hospital,Chaozhou 515600,Guangdong Province,China)

机构地区：[1]潮州市中心医院神经外科,广东潮州521000 [2]潮安康华医院综合科,广东潮州515600

出　　处：《中外医药研究》2025年第6期36-38,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析轻中度颅脑损伤患者血清降钙素原(PCT)、C反应蛋白(CRP)水平变化及其预测认知功能障碍(CI)的价值。方法:选取2022年5月—2023年12月潮州市中心医院收治的105例轻中度颅脑损伤患者作为观察组(轻微颅脑损伤48例为轻度组,中度颅脑损伤57例为中度组),另选取40例健康志愿者作为对照组。检测研究对象PCT、CRP水平,比较三组指标差异。评估观察组认知功能,根据结果将其分为nCI组(74例)与CI组(31例),分析PCT、CRP水平预测CI的价值。结果:入院后第1天,中度组PCT、CRP水平高于对照组与轻度组,轻度组高于对照组(P<0.05);入院后第3天,轻度组与中度组PCT、CRP水平升高,入院后第7天,两组PCT、CRP水平降低但高于入院后第1天,中度组高于轻度组(P<0.05)。入院后第3天,nCI与CI组PCT、CRP水平升高,入院后第7天,两组PCT、CRP水平降低但高于入院第1天,nCI组低于CI组(P<0.05)。入院后第3、7天的PCT、CRP水平预测轻中度颅脑损伤患者CI的价值均较高(AUC>0.8,P<0.001)。结论:轻中度颅脑损伤患者PCT、CRP水平高于健康人并与病情严重程度相关,且其水平预测颅脑损伤患者CI的价值较高。Objective:To analyze the changes in serum procalcitonin(PCT)and C-reactive protein(CRP)levels in patients with mild to moderate traumatic brain injury(TBI)and their predictive value for cognitive impairment(CI).Methods:From May 2022 to December 2023,105 patients with mild to moderate TBI admitted to Chaozhou Central Hospital were selected as the observation group(48 patients with mild TBI as the mild group and 57 patients with moderate TBI as the moderate group),and 40 healthy volunteers were selected as the control group.The levels of PCT and CRP were measured,and the differences among the three groups were compared.The cognitive function of the observation group was assessed,and the patients were divided into the noncognitive impairment(nCI)group(n=74)and the cognitive impairment(CI)group(n=31)based on the results.The predictive value of PCT and CRP levels for CI was analyzed.Results:On the first day after admission,the levels of PCT and CRP in the moderate group were higher than those in the control group and the mild group,and the levels in the mild group were higher than those in the control group(P<0.05).On the third day after admission,the levels of PCT and CRP in the mild and moderate groups increased.On the seventh day after admission,the levels of PCT and CRP in both groups decreased but were higher than those on the first day after admission,and the levels in the moderate group were higher than those in the mild group(P<0.05).On the third day after admission,the levels of PCT and CRP in the nCI and CI groups increased.On the seventh day after admission,the levels of PCT and CRP in both groups decreased but were higher than those on the first day after admission,and the levels in the nCI group were lower than those in the CI group(P<0.05).The levels of PCT and CRP on the third and seventh days after admission had high predictive value for CI in patients with mild to moderate TBI(AUC>0.8,P<0.001).Conclusion:The levels of PCT and CRP in patients with mild to moderate TBI were higher than those in healthy

关 键 词：轻中度颅脑损伤 降钙素原 C反应蛋白 认知功能障碍 

分 类 号：R651.15[医药卫生—外科学]