盐酸羟考酮联合丙泊酚用于内镜黏膜下剥离术的麻醉效果分析  

Analysis of Anesthetic Effect of Oxycodone Hydrochloride Combined with Propofol for Endoscopic Submucosal Dissection

作　　者：邵杜 张成功[2] 何恋 Shao Du;Zhang Chenggong;He Lian(People's Hospital of Yunnan Dehong Dai and Jingpo Autonomous Prefecture1,Dehong Dai and Jingpo Autonomous Prefecture 679200,Yunnan Province,China;Kunming Hospital of Traditional Chinese Medicine2,Kunming 650032,Yunnan Province,China)

机构地区：[1]云南德宏傣族景颇族自治州人民医院,云南德宏傣族景颇族自治州679200 [2]昆明市中医医院,云南昆明650032

出　　处：《中外医药研究》2025年第6期60-62,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析内镜黏膜下剥离术中采用盐酸羟考酮联合丙泊酚进行麻醉的应用效果。方法:选取2023年1—12月于云南德宏傣族景颇族自治州人民医院实施内镜黏膜下剥离术的患者80例作为研究对象,随机分为对照组(采用丙泊酚进行麻醉)和观察组(采用盐酸羟考酮联合丙泊酚进行麻醉),各40例。分析两组麻醉效果。结果:和用药前相比,两组用药15 min后、手术开始后30 min、手术结束前的心率、血氧饱和度、平均动脉压、呼吸频率均出现波动,观察组均优于对照组(P<0.05);观察组术中、术后不良反应发生率低于对照组(P<0.05);观察组麻醉相关指标均优于对照组(P<0.001);术后,两组血清皮质醇、去甲肾上腺素水平均升高,且观察组低于对照组(P<0.05)。结论:于内镜黏膜下剥离术麻醉中,联合应用盐酸羟考酮与丙泊酚的麻醉效果理想,可稳定患者生命体征,有效管控应激指标水平,用药安全性较高。Objective:To analyze the application effect of oxycodone hydrochloride combined with propofol in endoscopic submu⁃cosal dissection.Methods:Eighty patients undergoing endoscopic submucosal dissection at the People's Hospital of Yunnan De⁃hong Dai and Jingpo Autonomous Prefecture from January to December 2023 were selected as the study subjects.They were ran⁃domly divided into a control group(anesthetized with propofol)and an observation group(anesthetized with oxycodone hydrochlo⁃ride combined with propofol),with 40 patients in each group.The anesthetic effects of the two groups were analyzed.Results:Com⁃pared with before administration,the heart rate,blood oxygen saturation,mean arterial pressure,and respiratory rate of both groups fluctuated at 15 minutes after administration,30 minutes after the start of surgery,and before the end of surgery,with the observation group being superior to the control group(P<0.05).The incidence of intraoperative and postoperative adverse reac⁃tions in the observation group was lower than that in the control group(P<0.05).The anesthesia-related indicators of the observa⁃tion group were better than those of the control group(P<0.001).After surgery,the levels of serum cortisol and norepinephrine in both groups increased,with the observation group being lower than the control group(P<0.05).Conclusion:In the anesthesia for endoscopic submucosal dissection,the combined use of oxycodone hydrochloride and propofol provides an ideal anesthetic effect,stabilizes the patient's vital signs,effectively controls the levels of stress indicators,and has high medication safety.

关 键 词：盐酸羟考酮 丙泊酚 内镜黏膜下剥离术 应激指标 

分 类 号：R614[医药卫生—麻醉学]