血清肌酸激酶同工酶、羟丁酸脱氢酶和肌红蛋白水平与急性冠状动脉综合征的相关性  

Correlation between Serum Creatine Kinase Isoenzyme,Hydroxybutyrate Dehydrogenase,and Myoglobin Levels and Acute Coronary Syndrome

作　　者：张雄金 菊刘刚 Zhang Xiong;Jin Ju;Liu Gang(Department of Laboratory,Bijie Hezhang County People’s Hospital,Bijie 553200,Guizhou Province,China)

机构地区：[1]毕节市赫章县人民医院检验科,贵州毕节553200

出　　处：《中外医药研究》2025年第6期129-131,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨血清肌酸激酶同工酶(CK-MB)、羟丁酸脱氢酶(HBDH)和肌红蛋白(Myo)水平与急性冠状动脉综合征(ACS)的相关性。方法:选取2023年1—12月于毕节市赫章县人民医院就诊的129例ACS患者为观察组,另选取129例同期健康体检者为对照组。比较两组血清CK-MB、HBDH和Myo水平。根据全球急性冠状动脉事件注册(GRACE)评分将观察组分为低危组(GRACE评分≤108分,n=47)、中危组(GRACE评分109~140分,n=39)及高危组(GRACE评分>140分,n=43),比较低危组、中危组及高危组血清CK-MB、HBDH和Myo水平,并使用Spearman相关系数分析血清CK-MB、HBDH和Myo水平与ACS危险分层的相关性。结果:观察组CK-MB、HBDH、Myo水平高于对照组(P<0.001);高危组CK-MB、HBDH、Myo水平高于低危组及中危组,中危组CK-MB、HBDH、Myo水平高于低危组(P<0.05)。Spearman相关性分析结果显示,ACS患者病情危险分级与CK-MB、HBDH、Myo水平呈正相关(P<0.001)。结论:血清CK-MB、HBDH和Myo水平在ACS患者中显著升高,且与患者病情危重分级呈正相关。Objective:To investigate the correlation between serum creatine kinase isoenzyme(CK-MB),hydroxybutyrate dehydrogenase(HBDH),and myoglobin(Myo)levels and acute coronary syndrome(ACS).Methods:A total of 129 ACS patients admitted to Hezhang People's Hospital from January to December 2023 were selected as the observation group,and 129 healthy individuals undergoing physical examinations during the same period were selected as the control group.The serum levels of CKMB,HBDH,and Myo were compared between the two groups.Based on the Global Registry of Acute Coronary Events(GRACE)score,the observation group was further divided into a low-risk group(GRACE score≤108,n=47),a medium-risk group(GRACE score 109-140,n=39),and a high-risk group(GRACE score>140,n=43).The serum levels of CK-MB,HBDH,and Myo were compared among the low-risk,medium-risk,and high-risk groups,and the correlation between these serum markers and ACS risk stratification was analyzed using the Spearman correlation coefficient.Results:The levels of CK-MB,HBDH,and Myo in the observation group were significantly higher than those in the control group(P<0.001).The high-risk group exhibited higher levels of CK-MB,HBDH,and Myo compared to the low-risk and medium-risk groups,and the medium-risk group showed higher levels than the low-risk group(P<0.05).Spearman correlation analysis revealed that the disease risk grade of ACS patients was positively correlated with CK-MB,HBDH,and Myo levels(P<0.001).Conclusion:Serum CK-MB,HBDH,and Myo levels were significantly elevated in ACS patients and positively correlated with the severity of the disease.

关 键 词：急性冠状动脉综合征 肌酸激酶同工酶 羟丁酸脱氢酶 肌红蛋白 病情危险分级 

分 类 号：R541.4[医药卫生—心血管疾病]