SARS-CoV-2 Inhibits Exo-Endocytosis and Enhances Short-Term Depression at a Central Synapse  

作　　者：Jiawei Hu Yuhan Zhang Qingzhuo Liu Jiaqi Hu Yichen Ru Lu Zhang Lixin Xie Lei Xue 

机构地区：[1]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai,200438,China [2]Department of Physiology and Neurobiology,School of Life Sciences,Fudan University,Shanghai,200438,China [3]Department of Pulmonary and Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China [4]Center for Rehabilitation Medicine,Department of Pain Management,Zhejiang Provincial People’s Hospital,Affiliated People’s Hospital,Hangzhou Medical College,Hangzhou,310014,China [5]Department of Microbiology and Immunology,School of Life Sciences,Fudan University,Shanghai,200438,China [6]College of Pulmonary and Critical Care Medicine,8th Medical Center of Chinese PLA General Hospital,Beijing,100091,China [7]Research Institute of Intelligent Complex Systems,Fudan University,Shanghai,200433,China

出　　处：《Neuroscience Bulletin》2025年第1期165-171,共7页神经科学通报(英文版)

基　　金：sponsored by the National Key Research&Development Program of China(2022YFC3602700 and 2022YFC3602702);the Science and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project(2021ZD0201301);the National Natural Science Foundation of China(32170688 and 82172109);Shanghai Municipal Science and Technology Major Project(2018SHZDZX01),and ZJLab.

摘　　要：Dear Editor,SARS-CoV-2 is the virus that caused the COVID-19 pandemic,leading to more than 774 million cases and 7,037,007 deaths by March 2024(World Health Organization,http://covid19.who.int/).Despite effective treatments,15%-20%of patients experience long-term symptoms,such as breathlessness,fatigue,depression,and cognitive impairment,which are often linked to an excessive immune response[1].All variants of the virus(α,,,Omicron,and BA.1),which can potentially access the brain via the olfactory mucosa,have been found in the brains of Syrian hamsters,triggering inflammation and demonstrating axonal travel[2].

关 键 词：TRAVEL SPITE fatigue 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]