Neurotensin Modulates Emotional Valence Assignment in the Basolateral Amygdala Through Neuromodulator Gain  

作　　者：Maimaitishalijiang Abudureheman Yu-Hao Xiao Li-Zang Zeng Hong-Yan Geng 

机构地区：[1]Key Laboratory of Brain,Cognition and Education Science,Ministry of Education,South China Normal University,Guangzhou,510631,China [2]Institute for Brain Research and Rehabilitation,and Guangdong Key Laboratory of Mental Health and Cognitive Science,South China Normal University,Guangzhou,510631,China

出　　处：《Neuroscience Bulletin》2025年第1期177-180,共4页神经科学通报(英文版)

基　　金：supported by grants from the Key-Area Research and Development Program of Guangdong province(2019B030335001);the National Natural Science Foundation of China(32200815);the China Postdoctoral Science Foundation(2022M721218).

摘　　要：Based on previous experience,learning to avoid or seek certain specific stimuli again in the future is crucial for survival.Our brains are wired to assign a particular valence-either positive or negativeas a result of sensory stimuli,and it is this valence that serves as the foundational motivation for our subsequent actions.Simply put,all motivational actions fall into two categories:pleasure-seeking behavior guided by positive emotional valence,and pain-avoiding behavior driven by negative emotional valence[1].The ability to shift from one emotional valence to another is an important characteristic of affective states,while the instability of emotional states underlies many psychiatric disorders,highlighting the clinical importance of managing and understanding these fluctuations.This ability to adapt emotional responses can be attained by modulating the gain across distinct neural pathways,thus enabling the nuanced and smooth assignment of valence through the strengthening or weakening of circuit activity[1,2].

关 键 词：EMOTIONAL MOTIVATION MODULATOR 

分 类 号：H31[语言文字—英语]