Constructing A Theoretical Model to Bridge Neural Transition with a State Switch in Bipolar Disorder  

作　　者：Xiaonan Guo Lizichen Chen Jianbo Lai Shaohua Hu 

机构地区：[1]Department of Psychiatry,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310003,China [2]Department of Engineering Mechanics,Zhejiang University,Hangzhou,310027,China [3]Nanhu Brain-computer Interface Institute,Hangzhou,311100,China [4]The Zhejiang Key Laboratory of Precision Psychiatry,Hangzhou,310003,China [5]MOE Frontier Science Center for Brain Science and Brain-Machine Integration,Zhejiang University School of Medicine,Hangzhou,310003,China [6]Brain Research Institute of Zhejiang University,Hangzhou,310003,China [7]The State Key Lab of Brain-Machine Intelligence,Zhejiang University,Hangzhou,China [8]Zhejiang Engineering Center for Mathematical Mental Health,Hangzhou,310003,China

出　　处：《Neuroscience Bulletin》2025年第1期181-185,共5页神经科学通报(英文版)

基　　金：supported by the National Key Research and Development Program of China(2023YFC2506200);the Leading Talent of Scientific and Technological Innovation-"Ten Thousand Talents Program"of Zhejiang Province(2021R52016).

摘　　要：Reward or stress,which exists extensively,causes resilient emotional fluctuations under common situations.However,reward or stress is a typical trigger for manic or depressive episodes of bipolar disorder(BD),which is corroborated by psychological theory,biological findings,and psychosocial treatment approaches[1,2].During an episode of BD,the affective aberration can be persistent and switchable,accompanied by opposite constellations of cognitive and psychomotor symptoms.Characterized by uncontrollable mood ranging in severity,duration,and polarity,to disentangle the pathophysiology mechanism of BD is to delineate the mystery of affective fluctuations driven by reward or stress.

关 键 词：BIPOLAR TRANSITION finding 

分 类 号：TN2[电子电信—物理电子学]