“Now You See Me”:A Neural Pathway Independent of the Amygdala Responsible for Fear and Anxiety  

作　　者：Xiaojie Zhang Cenglin Xu Zhong Chen 

机构地区：[1]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,Jinhua Academy of Zhejiang Chinese Medical University,School of Pharmaceutical Science,Zhejiang Chinese Medical University,Hangzhou,310053,Zhejiang,China

出　　处：《Neuroscience Bulletin》2025年第1期186-188,共3页神经科学通报(英文版)

基　　金：supported by grants from the National Key R&D Program of China(2021ZD0202803);the National Natural Science Foundation of China(U21A20418).

摘　　要：Fear,as a type of psychological state and negative emotion,represents a common reflex towards the presence or imminence of danger.Clinically,fear-related disorders such as panic disorder and anxiety disorder can lead to impaired psychological and physiological conditions.Elucidating the neural basis of fear is of particular importance in developing targeted therapies.It is currently well-established that the amygdala plays a pivotal role in mediating various expressions of fear[1].However,silencing or inhibiting the amygdala only partially reduces fear-related behaviors[2],leading scientists to guess whether there exists an amygdalaindependent alternative neural pathway that conveys fear.Excitingly,a very recent elegant study published in Nature Neuroscience by Wang et al.from Zhejiang University has addressed this question.They present a tetra-synaptic forebrain-to-hindbrain pathway that is responsible for odordriven innate fear and anxiety(Fig.1)[3].

关 键 词：Independent IMPAIRED DATING 

分 类 号：H31[语言文字—英语]