异基因造血干细胞移植治疗慢性NK细胞淋巴增殖性疾病合并急性髓系白血病1例  

Allogeneic hematopoietic stem cell transplantation treatment for chronic lymphoproliferative disorder of natural killer cells combined with acute myeloid leukemia: a case report

作　　者：王佳雯 缪扣荣[1] 朱晗[1] WANG Jiawen;MIAO Kourong;ZHU Han(Department of Hematology,the First Affiliated Hospital with Nanjing Medical University,Jiangsu Province Hospital,Nanjing,210029,China)

机构地区：[1]南京医科大学第一附属医院,江苏省人民医院血液科,南京210029

出　　处：《临床血液学杂志》2025年第1期73-76,共4页Journal of Clinical Hematology

摘　　要：慢性NK细胞淋巴增殖性疾病(CLPD-NK)是一种罕见的成熟自然杀伤(NK)细胞淋巴增殖性疾病。本文报道1例CLPD-NK合并急性髓系白血病(AML)的病例,临床上极为罕见。本例患者长期白细胞减少,经过骨髓检查及NK细胞克隆性筛查确诊CLPD-NK,予以激素联合免疫抑制剂治疗。后患者骨髓检查提示原始细胞增多,流式提示髓系表达,考虑CLPD-NK合并AML,经过化疗及异基因造血干细胞移植后,无病生存至今。Chronic lymphoproliferative disorder of natural killer cells(CLPD-NK)is a rare mature natural killer(NK)cell lymphoproliferative disorder.This article reports a case of CLPD-NK combined with acute myeloid leukemia(AML),which is extremely rare in clinical practice.The patient had a long history of leukopenia and was diagnosed with CLPD-NK through bone marrow examination and NK cell clonality screening.Treatment with glucocorticoids combined with immunosuppressants was applied.Subsequently,bone marrow examination revealed an increase in blats and flow cytometry suggested myeloid expression,leading to the consideration of CLPD-NK combined with AML.After chemotherapy and allogeneic hematopoietic stem cell transplantation,the patient has remained disease-free to this day.

关 键 词：慢性NK细胞淋巴增殖性疾病 急性髓系白血病 异基因造血干细胞移植 

分 类 号：R551.2[医药卫生—血液循环系统疾病] R733.7[医药卫生—内科学]