葛根素防治子痫前期作用机制的研究进展  

Research progress on mechanism of puerarin in preventing and treating preeclampsia

作　　者：刘敏 赵小卫 胡昌瑜 LIU Min;ZHAO Xiaowei;HU Changyu(Department of Obstetrics,the People's Hospital of Dazu,Chongqing,Chongqing 402360,China)

机构地区：[1]重庆市大足区人民医院产科,重庆402360

出　　处：《现代药物与临床》2025年第2期520-524,共5页Drugs & Clinic

基　　金：重庆市大足区科技发展项目(DZKJ2024JSYJ-KWXM1062)。

摘　　要：子痫前期是一种严重妊娠并发症,临床治疗以解痉药物、抗凝药物、降压药物为主。葛根素是由葛根中提取的异黄酮类成分,具有一系列生物活性,可通过改善血管内皮功能、减轻氧化应激反应、减轻炎症反应、抑制滋养层细胞过度凋亡、增强抗缺氧能力、改善滋养层细胞运动功能、降低胰岛素抵抗发挥治疗子痫前期的作用。综述了葛根素防治子痫前期的作用机制研究进展,为子痫前期的药物治疗提供参考。Preeclampsia is a serious complication of pregnancy,and clinical treatment mainly includes antispasmodic drugs,anticoagulants,and antihypertensive drugs.Puerarin is a flavonoid component extracted from Puerariae Lobatae Radix,with series of biological activities,and can improve endothelial function of blood vessels,alleviate oxidative stress response,reduce inflammatory response,inhibit excessive apoptosis of trophoblast cells,enhance anti-hypoxia ability,improve trophoblast cell motility,reduce insulin resistance,and exert therapeutic effects on preeclampsia through multiple pathways.This article reviews the research progress of mechanism of puerarin in prevention and treatment of preeclampsia,and provides reference for the drug treatment of preeclampsia.

关 键 词：葛根素 子痫前期 血管内皮功能 氧化应激反应 炎症反应 滋养层细胞 缺氧能力 运动功能 胰岛素抵抗 

分 类 号：R972[医药卫生—药品]