黄芩素抗乳腺癌的研究进展  

Research progress on baicalin against breast cancer

作　　者：钟宪澎 孙健 王志国 孙中明 张军 ZHONG Xianpeng;SUN Jian;WANG Zhiguo;SUN Zhongming;ZHANG Jun(Nursing Department,Jilin University Hospital,Changchun 130012,China;Department of Health Care,Jilin University Hospital,Changchun 130012,China;Department of Pharmacy,Jilin University Hospital,Changchun 130012,China;Internal and External Treatment Area,Jilin University Hospital,Changchun 130012,China;General Surgery,Jilin Province First Automobile General Hospital,Changchun 130011,China)

机构地区：[1]吉林大学校医院护理部,吉林长春130012 [2]吉林大学校医院保健科,吉林长春130012 [3]吉林大学校医院药剂科,吉林长春130012 [4]吉林大学校医院内外疗区,吉林长春130012 [5]吉林省一汽总医院普通外科,吉林长春130011

出　　处：《现代药物与临床》2025年第2期525-531,共7页Drugs & Clinic

摘　　要：乳腺癌为女性常见恶性肿瘤之一,是导致女性癌症死亡的第2大恶性肿瘤,发病人群逐渐增多且呈年轻化趋势。乳腺癌的传统放化疗存在严重不良反应,限制了长期使用。黄芩素是由黄芩干燥根中提取的天然黄酮类成分,可通过抑制细胞增殖、阻滞肿瘤细胞侵袭和转移、促进细胞凋亡、逆转细胞耐药性发挥抗乳腺癌的作用。总结了黄芩素抗乳腺癌的研究进展,希望为乳腺癌的药物治疗提供参考。Breast cancer is one of the common malignant tumors in women and the second leading cause of cancer death in women.The incidence is gradually increasing and is showing a trend of younger age.Traditional radiotherapy and chemotherapy for breast cancer have serious adverse reactions,which limit long-term use.Baicalin is a natural flavonoid component extracted from dried roots of Scutellariae Radix.Baicalein can play an anti-breast cancer role by inhibiting cell proliferation,limiting tumor cell invasion and metastasis,promoting cell apoptosis,and reversing cell resistance.This article summarizes the research progress of baicalein against breast cancer,hoping to provide a reference for drug therapy of breast cancer.

关 键 词：黄芩素 乳腺癌 细胞增殖 侵袭 转移 细胞凋亡 耐药性 

分 类 号：R979.1[医药卫生—药品]