2019—2023年珠三角某市华支睾吸虫病疾病负担研究  

Study on the burden of clonorchiosis in a city of the pearl river delta from 2019 to 2023

作　　者：钟杰发 王曼[1] 罗乐[1] 黄宗杰[1] ZHONG Jie-fa;WANG Man;LUO Le;HUANG Zong-jie(Zhongshan Center for Disease Control and Prevention,Zhongshan,Guangdong 528403,China)

机构地区：[1]中山市疾病预防控制中心,广东中山528403

出　　处：《现代预防医学》2025年第3期424-429,共6页Modern Preventive Medicine

摘　　要：目的分析和评估珠三角某市华支睾吸虫病感染人群特征和疾病负担,为下一步防治策略提供科学依据。方法依据2019—2023年珠三角某市华支睾吸虫病的人群监测、医疗机构数据,计算不同性别、年龄组的感染率和感染度占比,描述就诊病例特征和使用伤残调整寿命年(disability-adjusted life years,DALYs)评价疾病负担。结果2019—2023年珠三角某市华支睾吸虫病人群调查感染率为8.32%,男性感染率为12.50%,女性感染率为4.84%,男女差异具有统计学意义(χ^(2)=98.54,P<0.001)。经加权感染率为7.87%[95%置信区间(confidence interval,CI):5.67%~10.06%]。各年龄组加权感染率介于0.09%~16.18%,40岁以上年龄组感染率高。感染者感染度以轻度感染为主,占97.00%,中、重度感染占比低。每年华支睾吸虫病男性损失的DALYs为14399.10人年,女性为4606.71人年,合计19005.81人年,每1000人口损失DALYs为4.76人年。2019—2023年累积有3193名华支睾吸虫病病例前往医疗机构就诊,以门诊为主,占95.49%;出现胆石症、胆囊炎、胆管炎、肝囊肿、胆囊息肉、胆囊切除术、胆囊肥大、肝胆管癌比例分别为1.16%、0.60%、0.53%、0.22%、0.06%、0.06%、0、0;门诊平均医疗费用为155.62元,住院平均医疗费用为6545.97元。结论珠三角某市华支睾吸虫病疾病负担较重,主要表现为人群感染率高,感染人群以男性、中老年人、轻度感染为主,下一步应针对重点人群开展宣传教育和筛查治疗。Objective To analyze and assess the characteristics of the infected population and the disease burden of clonorchiosis in a city of the Pearl River Delta,providing a scientific basis for future prevention and control strategies.Methods Based on population monitoring and medical institution data from 2019 to 2023 regarding clonorchiosis in the city,infection rates and prevalence proportions were calculated for different genders and age groups.The characteristics of patients seeking medical attention were described,and the disease burden was evaluated using Disability-adjusted Life Years(DALYs).Results The overall infection rate for clonorchiosis in the surveyed population from 2019 to 2023 was 8.32%,with a male infection rate of 12.50% and a female infection rate of 4.84%,showing a statistically significant difference(χ^(2)=98.54,P<0.001).The weighted infection rate was 7.87%[95%Confidence Interval(CI):5.67%-10.06%].The weighted infection rates across various age groups ranged from 0.09%to 16.18%,with higher rates observed in individuals over 40 years of age.The majority of infections were mild(97.00%),while moderate and severe infections were less common.The annual DALYs lost due to clonorchiosis were 14399.10 for males and 4606.71 for females,totaling 19005.81,equating to a loss of 4.76 DALYs per 1000 people per year.From 2019 to 2023,a total of 3193 cases of clonorchiosis sought medical attention,primarily through outpatient services(95.49%).The proportions of complications such as cholelithiasis,cholecystitis,cholangitis,liver cysts,gallbladder polyps,cholecystectomy,gallbladder hypertrophy,and cholangiocarcinoma were 1.16%,0.60%,0.53%,0.22%,0.06%,0.06%,0.00%,and 0.00%,respectively.The average outpatient medical cost was 155.62 yuan,while the average inpatient medical cost was 6545.97 yuan.Conclusion The burden of clonorchiosis in the city of the Pearl River Delta is significant,characterized by a high population infection rate,primarily among males,middle-aged and elderly individuals,and mild infections.Futu

关 键 词：华支睾吸虫病 疾病负担 伤残调整寿命年 

分 类 号：R523.23[医药卫生—内科学]