系统性免疫炎症指数与成人肥胖之间的关联性研究  

Study on the association between systemic immune-inflammation index and adult obesity

作　　者：朱文 邹游 谢林伸 ZHU Wen;ZOU You;XIE Lin-shen(West China School of Public Health/West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院,四川成都610041

出　　处：《现代预防医学》2025年第3期565-570,共6页Modern Preventive Medicine

摘　　要：目的探讨系统性免疫炎症指数(systemic immune-inflammation index,SII)与成人肥胖之间的关联性,为肥胖的预防和早期诊断提供思路。方法本研究基于美国国家健康和营养调查(NHANES)的调查数据。采用二分类logistic回归模型通过计算比值比(OR)及其95%置信区间(CI)评估SII与肥胖(一般性肥胖、向心性肥胖)之间的关系。此外,按年龄(<60岁和≥60岁)和性别进行分层分析。结果调整所有协变量后。以一般性肥胖为结局变量时,与SII最低四分位数(Q1)的研究对象相比,第三分位数(Q3)研究对象患一般性肥胖的风险增加了0.374倍(OR=1.374,95%CI:1.111~1.699);第四分位数(Q4)研究对象患一般性肥胖的风险增加了0.843倍(OR=1.843,95%CI:1.490~2.281)。以向心性肥胖为结局变量时,与Q1的研究对象相比,Q3研究对象患向心性肥胖的风险增加了0.542倍(OR=1.542,95%CI:1.189~2.000);Q4研究对象患向心性肥胖的风险增加了1.036倍(OR=2.036,95%CI:1.553~2.670)。此外,分层分析结果显示:SII与肥胖的关系在不同年龄中存在差异,仅在年龄<60岁的人群中显著。结论SII与成人肥胖患病风险呈正相关,且SII越高,肥胖的患病风险越高。此外,SII与肥胖的关系可能具有年龄特异性。Objective To explore the association between the systemic immune-inflammation index(SII)and adult obesity,and to provide insights for the prevention and early diagnosis of obesity.Methods This study was based on the survey data of the National Health and Nutrition Examination Survey(NHANES).A binary logistic regression model was used to evaluate the relationship between the systemic immune-inflammation index and obesity(general obesity,central obesity)by calculating the odds ratio(OR)and its 95%confidence interval(CI).In addition,stratified analysis was performed by age(<60 years old and≥60 years old)and gender.Results After adjusting all covariates,when general obesity was taken as the outcome variable,compared with the subjects in the lowest quartile(Q1)of SII,the risk of general obesity in the subjects in the third quartile(Q3)increased by 0.374 times(OR=1.374,95%CI:1.111-1.699);the risk of general obesity in the subjects in the fourth quartile(Q4)increased by 0.843 times(OR=1.843,95%CI:1.490-2.281).When central obesity was taken as the outcome variable,compared with the subjects in Q1,the risk of central obesity in the subjects in Q3 increased by 0.542 times(OR=1.542,95%CI:1.189-2.000);the risk of central obesity in the subjects in Q4 increased by 1.036 times(OR=2.036,95%CI:1.553-2.670).In addition,the results of stratified analysis showed that the relationship between SII and obesity was different among different ages and was only significant in the population aged<60 years old.Conclusion SII is positively correlated with the risk of adult obesity,and the higher the SII,the higher the risk of obesity.In addition,the relationship between SII and obesity may be age-specific.

关 键 词：肥胖 系统性免疫炎症指数 国家健康和营养调查 

分 类 号：R589.2[医药卫生—内分泌]