冠状动脉CTA量化脂肪衰减指数指导冠状动脉非钙化斑块危险分层的价值  

Quantitative fat attenuation index derived from coronary CTA for risk stratification of non-calcified coronary plaques

作　　者：刘学谦 秦涛 丁倩倩 LIU Xueqian;QIN Tao;DING Qianqian(CT Room,Qinhuangdao Workers’Hospital,Qinhuangdao 066200,China;Department of Radiology,Qinhuangdao Workers’Hospital,Qinhuangdao 066200,China)

机构地区：[1]秦皇岛市工人医院CT室,河北秦皇岛066200 [2]秦皇岛市工人医院放射科,河北秦皇岛066200

出　　处：《中国中西医结合影像学杂志》2025年第2期228-231,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：2024年度河北省医学科学研究课题计划(20241033)。

摘　　要：目的:通过冠状动脉CT血管成像(CCTA)量化脂肪衰减指数(FAI),分析FAI对冠状动脉非钙化斑块危险分层的指导价值。方法:选取行CCTA检查且有非钙化斑块的患者160例为非钙化斑块组;另抽取同期行CCTA检查无病变的患者50例为对照组;按管腔狭窄程度,将非钙化斑块组分为轻度组72例、中度组53例及重度组35例。检测所有患者的FAI,分析非钙化斑块管腔狭窄程度与FAI的相关性及FAI对非钙化斑块危险分层的评估价值。结果:非钙化斑块组FAI高于对照组(P<0.05);轻、中、重度组FAI比较,差异有统计学意义(P<0.05),轻度组低于中度组、重度组(均P<0.05),中度组与重度组差异无统计学意义(均P>0.05)。Pearson相关性分析显示,非钙化斑块管腔狭窄程度与FAI呈正相关(r=0.523,P<0.05)。ROC曲线分析显示,FAI评估非钙化斑块危险分层的AUC、特异度及敏感度分别为0.710、70.50%、75.00%。结论:CCTA量化的FAI与非钙化斑块管腔狭窄程度呈正相关,且对非钙化斑块危险分层有一定指导价值,可作为评估冠状动脉疾病患者斑块进展及严重程度的重要指标。Objective:To evaluate the clinical utility of coronary CTA-derived fat attenuation index(FAI)in risk stratification of non-calcified plaques.Methods:A total of 160 patients with non-calcified plaques identified by coronary CTA(non-calcified plaque group)and 50 controls without coronary lesions(control group)were enrolled.The non-calcified plaque group was further stratified by luminal stenosis severity into mild(72 cases),moderate(53 cases),and severe(35 cases)subgroups.FAI measurements were performed for all participants.The correlation between the luminal stenosis degree and FAI was analyzed,as well as the value of FAI in risk stratification of non-calcified plaques.Results:The non-calcified plaque group demonstrated significantly higher FAI compared to the control group(P<0.05).FAI had significant differences in mild,moderate,severe subgroups in the non-calcified plaque group(P<0.05).FAI in the mild subgroup was lower than that of the moderate and severe subgroups(bothe P<0.05),while no significant difference was found in FAI between the moderate subgroup and the severe subgroup(P>0.05).Pearson analysis revealed a positive correlation between FAI and luminal stenosis severity(r=0.523,P<0.05).The ROC curve indicated that the AUC,specificity and sensitivity of FAI in risk stratification of non-calcified plaques were 0.710,70.50%and 75.00%,respectively.Conclusions:Coronary CTA-derived FAI correlates positively with luminal stenosis severity in non-calcified plaques and shows clinically relevant utility for plaque risk stratification,serving as a promising quantitative biomarker for assessing coronary plaque progression and cardiovascular risk.

关 键 词：冠状动脉 脂肪衰减指数 非钙化斑块 危险分层 体层摄影术 X线计算机 

分 类 号：R54[医药卫生—心血管疾病]